Conformational Variability: Implications for Biomolecular Activity and in Drug Design
Formation of a protein-ligand complex is opposed by the loss of rotational, translational and conformational degrees of freedom, but if the ligand binds in a conformation that does not corresponds to the global minimum, an energetic penalty should also be expected. Although it is well known that the...
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| Format: | Doctoral Thesis |
| Language: | English |
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Universitat de Barcelona
2012
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| Online Access: | http://hdl.handle.net/10803/81467 |