Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues

A practical method for the synthesis of an isoquinoline alkaloid 6,7-dimethoxy-2-methylisoquinoline-1,3,4(2H)-trione and its analogues has been demonstrated. Two new methods for synthesizing substituted phthalonimides from the corresponding isocarbostyrils have been developed. Phthalonimide derivati...

Full description

Bibliographic Details
Main Author:	Huang, Yijun
Other Authors:	David E. Minter
Format:	Others
Language:	en
Published:	Texas Christian University 2008
Subjects:	College of Science and Engineering
Online Access:	http://etd.tcu.edu/etdfiles/available/etd-07232008-163440/

id	ndltd-TCU-oai-etd.tcu.edu-etd-07232008-163440
record_format	oai_dc
spelling	ndltd-TCU-oai-etd.tcu.edu-etd-07232008-1634402013-01-08T02:48:37Z Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues Huang, Yijun College of Science and Engineering A practical method for the synthesis of an isoquinoline alkaloid 6,7-dimethoxy-2-methylisoquinoline-1,3,4(2H)-trione and its analogues has been demonstrated. Two new methods for synthesizing substituted phthalonimides from the corresponding isocarbostyrils have been developed. Phthalonimide derivatives were obtained by the oxidation of isocarbostyrils protected with methoxymethyl and â,â,â-trichloroethoxymethyl groups. The direct oxidation of isocarbostyrils under different conditions was also investigated. In addition, six dienes for potential use in the development of a [4+2] cycloaddition approach to galanthan tetracyclic ring system have been synthesized. These precursors and dienophiles are based on and drived from isoquinolines and isocarbostyrils. David E. Minter Texas Christian University 2008-07-23 text application/pdf http://etd.tcu.edu/etdfiles/available/etd-07232008-163440/ http://etd.tcu.edu/etdfiles/available/etd-07232008-163440/ en unrestricted I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to TCU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection	NDLTD
language	en
format	Others
sources	NDLTD
topic	College of Science and Engineering
spellingShingle	College of Science and Engineering Huang, Yijun Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues
description	A practical method for the synthesis of an isoquinoline alkaloid 6,7-dimethoxy-2-methylisoquinoline-1,3,4(2H)-trione and its analogues has been demonstrated. Two new methods for synthesizing substituted phthalonimides from the corresponding isocarbostyrils have been developed. Phthalonimide derivatives were obtained by the oxidation of isocarbostyrils protected with methoxymethyl and â,â,â-trichloroethoxymethyl groups. The direct oxidation of isocarbostyrils under different conditions was also investigated. In addition, six dienes for potential use in the development of a [4+2] cycloaddition approach to galanthan tetracyclic ring system have been synthesized. These precursors and dienophiles are based on and drived from isoquinolines and isocarbostyrils.
author2	David E. Minter
author_facet	David E. Minter Huang, Yijun
author	Huang, Yijun
author_sort	Huang, Yijun
title	Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues
title_short	Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues
title_full	Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues
title_fullStr	Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues
title_full_unstemmed	Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues
title_sort	transformations of isocarbostyrils for the synthesis of isoquinoline alkaloids and the related analogues
publisher	Texas Christian University
publishDate	2008
url	http://etd.tcu.edu/etdfiles/available/etd-07232008-163440/
work_keys_str_mv	AT huangyijun transformationsofisocarbostyrilsforthesynthesisofisoquinolinealkaloidsandtherelatedanalogues
_version_	1716502565936431104

Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues

Similar Items