Effect of Transcatheter Aortic Valve Replacement on Right Ventricular Function| Meta analyses and Systematic Review

• Main Author: Zahaf, Marwah
• Language: EN
• Published: Rush University 2016
• Subjects: Medicine|Health sciences|Medical imaging
• Online Access: http://pqdtopen.proquest.com/#viewpdf?dispub=1581898

<p> <b>Objectives:</b> We ought to compare the effect of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) on right ventricular systolic function (RVSF) in high risk patients with severe aortic stenosis (AS). <b>Methodology: Data Source</b>. PubMed, EMBASE, Cochrane library, and references of selected articles. Study Endpoints. Transthoracic echocardiography was utilized to assess the change in RVSF post TAVR versus SAVR using tricuspid annular plane systolic excursion (TAPSE), and Fractional area change (RVFAC). <b>Statistical analyses</b>. Random effect model on standardized mean difference (Hedges; g) were used together with heterogeneity assessment. <b>Result:</b> We included 485 patients from five single-center observational studies. Comparing TAVR with SAVR, TAVR resulted in better improvement in RVSF [TAPSE (<i>g</i>=2.88, SE=0.63, <i>P</i>&lt;0.001, Q=73.18, /²=94.53, r=0.65), and RVFAC (<i>g</i>=0.91, SE=0.16, <i>P</i>&lt;0.001, Q=2.39, /²=16.61), r=0.65]. <b> Conclusion:</b> Compared with SAVR, TAVR is preferred aortic intervention in patients with severe symptomatic AS and RV systolic dysfunction.</p>