Therapeutic Dual-targeting of Cytosolic and Mitochondrial One-carbon Metabolism
One-carbon metabolism (1CM) is compartmentalized in the mitochondria and cytosol and generates a host of metabolites critical to tumor propagation. Although drug-targeting of cytosolic 1CM remains a clinically-relevant mainstay, development of clinically-useful agents targeting mitochondrial 1CM rem...
| Main Author: | |
|---|---|
| Language: | ENG |
| Published: |
Wayne State University
2021
|
| Subjects: | |
| Online Access: | http://pqdtopen.proquest.com/#viewpdf?dispub=13812930 |