| Summary: | <p> <i>Salmonella enterica</i> serovar Typhimurium (<i>S. </i> Typhimurium) is a pathogenic gram negative bacteria. Secretion systems are necessary for cell processes and for virulence. The Twin Arginine Translocation system (Tat) translocates folded proteins through the cytoplasmic membrane into the periplasmic space. Regulation of Tat in <i>S.</i> Typhimurium has not been elucidated. In <i>E. coli,</i> regulation of Tat has been briefly studied, but was thought to be constitutively expressed. This study provides evidence that in <i>S.</i> Typhimurium, <i> tat</i> expression is upregulated when grown in bile salts and indole, and possibly downregulated when grown in elevated temperatures. Additionally, evidence is presented that the regulation induced by indole occurs through action of the σE, PhoPQ, and CpxA/R regulatory systems. The regulation of <i>tat</i> induce by bile is not through σE, PhoPQ, BarA/SirA, BaeS/R or CpxA/R.</p><p>
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