Purification and Characterization of Type 5 Staphylococcus aureus

Purification and Characterization of Type 5 Staphylococcus aureus

Bibliographic Details
Main Author: Rudnicki, Thomas
Language:English
Published: Youngstown State University / OhioLINK 2010
Subjects:
Biology
Chemistry
Antibiotic resistant Staphylococcus aureus
Capsular polysaccharide
Glycobiology
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288363170
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ysu12883631702021-08-03T06:17:54Z Purification and Characterization of Type 5 Staphylococcus aureus Rudnicki, Thomas Biology Chemistry Antibiotic resistant Staphylococcus aureus Capsular polysaccharide Glycobiology <i>Staphylococcus aureus (S. aureus)</i> infections are notoriously difficult to treat due to antibiotic resistance and virulence. One virulence factor employed by <i>S. aureus</i> is a protective polysaccharide coating called a capsule. This structural component plays a significant role in immune response evasion. Drugs that target bacterial capsule circumvent the mechanisms utilized by traditional antibiotics and create a novel way to treat <i>S. aureus</i> infections. A systematic purification and characterization of the capsule can further drug development by elucidating the immunological interaction of this element. Purification of the capsule was achieved by implementing ion-exchange, sizeexclusion chromatography, and enzymatic digestion. The purified sample was thencharacterized by NMR spectroscopy. 2010-11-01 English text Youngstown State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288363170 http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288363170 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
Chemistry
Antibiotic resistant Staphylococcus aureus
Capsular polysaccharide
Glycobiology
spellingShingle Biology
Chemistry
Antibiotic resistant Staphylococcus aureus
Capsular polysaccharide
Glycobiology
Rudnicki, Thomas
Purification and Characterization of Type 5 Staphylococcus aureus
author Rudnicki, Thomas
author_facet Rudnicki, Thomas
author_sort Rudnicki, Thomas
title Purification and Characterization of Type 5 Staphylococcus aureus
title_short Purification and Characterization of Type 5 Staphylococcus aureus
title_full Purification and Characterization of Type 5 Staphylococcus aureus
title_fullStr Purification and Characterization of Type 5 Staphylococcus aureus
title_full_unstemmed Purification and Characterization of Type 5 Staphylococcus aureus
title_sort purification and characterization of type 5 staphylococcus aureus
publisher Youngstown State University / OhioLINK
publishDate 2010
url http://rave.ohiolink.edu/etdc/view?acc_num=ysu1288363170
work_keys_str_mv AT rudnickithomas purificationandcharacterizationoftype5staphylococcusaureus
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