Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice

Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice

Bibliographic Details
Main Author: Vaughan, Parker Andrew
Language:English
Published: Wright State University / OhioLINK 2020
Subjects:
Neurosciences
Neurobiology
Neurology
conduction velocity
methylglyoxal
optic nerve
electrophysiology
diabetes
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=wright1590769538838536
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-wright15907695388385362021-08-03T07:15:11Z Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice Vaughan, Parker Andrew Neurosciences Neurobiology Neurology conduction velocity methylglyoxal optic nerve electrophysiology diabetes The nervous system is responsible for interpreting information and coordinating that organism’s physiological response. Action potentials conduct along neuron axons to carry information within the nervous system. Saltatory conduction allows the action potential to travel rapidly along the axon from one Node of Ranvier to the next. Nodes of Ranvier are densely packed with different proteins, notably voltage-gated sodium channels (Nav). Methylglyoxal, a toxic metabolite of glycolysis that is elevated in diabetes mellitus, alters nerve excitability by eliciting changes in protein function and structure within the Nodes of Ranvier. This study investigated the effects of methylglyoxal exposure on nerve conduction in optic nerves of mice, to test the hypothesis that methylglyoxal exposure would decrease conduction velocity. The conduction velocity, peak amplitude, and latency of optic nerve compound action potentials were recorded from saline- and methylglyoxal-treated mice. While results did not reach statistical significance, trends were evident in the analyzed parameters. 2020-06-07 English text Wright State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=wright1590769538838536 http://rave.ohiolink.edu/etdc/view?acc_num=wright1590769538838536 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Neurosciences
Neurobiology
Neurology
conduction velocity
methylglyoxal
optic nerve
electrophysiology
diabetes
spellingShingle Neurosciences
Neurobiology
Neurology
conduction velocity
methylglyoxal
optic nerve
electrophysiology
diabetes
Vaughan, Parker Andrew
Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice
author Vaughan, Parker Andrew
author_facet Vaughan, Parker Andrew
author_sort Vaughan, Parker Andrew
title Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice
title_short Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice
title_full Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice
title_fullStr Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice
title_full_unstemmed Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice
title_sort electrophysiology of optic nerves in methylglyoxal treated mice
publisher Wright State University / OhioLINK
publishDate 2020
url http://rave.ohiolink.edu/etdc/view?acc_num=wright1590769538838536
work_keys_str_mv AT vaughanparkerandrew electrophysiologyofopticnervesinmethylglyoxaltreatedmice
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