IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE

Bibliographic Details
Main Author:	Gosky , Brenna Colleen
Language:	English
Published:	Wright State University / OhioLINK 2014
Subjects:	Neurosciences neurosciences
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=wright1409674183

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-wright14096741832021-08-03T06:27:26Z IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE Gosky , Brenna Colleen Neurosciences neurosciences In animals proprioceptive Ia afferents enable the animal to sense the location, orientation and movement of its limbs in space. These Ia afferents make connections with many different types of neurons within the spinal cord such as; motor neurons, Ia Inhibitory interneurons, and other interneurons. Ia Afferents connect with IaINs that project to antagonist muscle MNs to ensure that contraction of the antagonist muscle group is inhibited. For example the quadriceps Ia afferents contact IaINs that contact PBST motor neurons to inhibit excitation and thus contraction. The way in which the connectivity of these Ia afferents is established is not entirely understood. Complete genetic control of connectivity would be overly complicated, and while it probably does play a part there seems to be changes in the connectivity that occur during development, and even after birth some refinement may occur. To investigate plasticity in connectivity, we mapped the connections of Ia afferents of the quadriceps and obturator nerves onto Ia inhibitory interneurons of animals at and shortly after birth (P0/P1 timepoint). The known characteristics of Ia Inhbitory interneurons were used to identify them, glycine being used as the neurotransmitter, calbindin contacts from Renshaw cells, and afferent contact. The IaINs were placed into three categories those receiving quad afferent contact, those receiving obturator afferent contact, and those receiving both afferent contact. Out of the 437 Ia inhibitory interneurons analyzed in 3 animals 26.5% received contacts from both quadriceps and obturator Ia afferents. This is surprising because Adductor afferents should not contact the same IaINs as quad afferents, because there is no reciprocal inhibition seen in the PBST when the obturator is stimulated as it is with stimulation of the quad nerve. This suggests that there are some activity dependent changes that occur to refine the circuit of reciprocal inhibition after birth. 2014-09-03 English text Wright State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=wright1409674183 http://rave.ohiolink.edu/etdc/view?acc_num=wright1409674183 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Neurosciences neurosciences
spellingShingle	Neurosciences neurosciences Gosky , Brenna Colleen IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE
author	Gosky , Brenna Colleen
author_facet	Gosky , Brenna Colleen
author_sort	Gosky , Brenna Colleen
title	IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE
title_short	IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE
title_full	IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE
title_fullStr	IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE
title_full_unstemmed	IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE
title_sort	ia afferent connectivity with glycinergic interneurons in early postnatal mice
publisher	Wright State University / OhioLINK
publishDate	2014
url	http://rave.ohiolink.edu/etdc/view?acc_num=wright1409674183
work_keys_str_mv	AT goskybrennacolleen iaafferentconnectivitywithglycinergicinterneuronsinearlypostnatalmice
_version_	1719437330237882368

IA AFFERENT CONNECTIVITY WITH GLYCINERGIC INTERNEURONS IN EARLY POSTNATAL MICE

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