RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION

RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION

Bibliographic Details
Main Author: Murdock, Richard Craig
Language:English
Published: Wright State University / OhioLINK 2010
Subjects:
Biology
Biomedical Research
Chemical Engineering
Electromagnetism
Engineering
Materials Science
Physics
Remote Sensing
nanomaterials
gold
silver
radio frequency
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=wright1277753458
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-wright12777534582021-08-03T06:17:12Z RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION Murdock, Richard Craig Biology Biomedical Research Chemical Engineering Electromagnetism Engineering Materials Science Physics Remote Sensing nanomaterials gold silver radio frequency The objective of this investigation was to further explore the ability of a radio frequency (RF) signal to interact with metal nanoparticles (NPs) for the purposes of remote stimulation or control of cellular processes. Gold and silver NPs have shown the ability to be heated by electromagnetic frequencies, especially for the purpose of deactivating abnormal cells. However, the heating of the NPs in these previous studies was constant and uncontrolled. For this study, our hypothesis was by investigating the RF heating characteristics of NPs and its impact on surface functionalizations, a remotely stimulated control mechanism can be developed at the nanoscale, with applications in the control of cellular signaling. Spherical gold nanoparticles (Au NPs, 4nm and 13nm) and spherical silver nanoparticles (Ag NPs, 8nm) were synthesized, biofunctionalized with oligonucleotides, and hybridized through the oligonucleotide functionalization as a potential method of intracellular control. Initial Au and Ag NP heating studies were conducted by exposure to a 13.56 MHz RF frequency at 400W power output for 180 seconds and sample solution temperature was measured via infrared thermal imaging. Unfunctionalized Au and Ag NPs were tested with all samples showing significant heating of greater than 40°C. Biofunctionalized Au and Ag NPs showed significantly less heat transfer to solution, indicating most heat transfer was absorbed by oligonucleotide. Biocompatibility assessment studies were also conducted on the unfunctionalized and functionalized Au and Ag NPs and did not show any significant impact on cell viability after 24 hours. In summary, the feasibility of NP surface functionalization through RF heating is shown with investigation into the NP heating and heat transfer mechanisms. 2010-06-29 English text Wright State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=wright1277753458 http://rave.ohiolink.edu/etdc/view?acc_num=wright1277753458 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
Biomedical Research
Chemical Engineering
Electromagnetism
Engineering
Materials Science
Physics
Remote Sensing
nanomaterials
gold
silver
radio frequency
spellingShingle Biology
Biomedical Research
Chemical Engineering
Electromagnetism
Engineering
Materials Science
Physics
Remote Sensing
nanomaterials
gold
silver
radio frequency
Murdock, Richard Craig
RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION
author Murdock, Richard Craig
author_facet Murdock, Richard Craig
author_sort Murdock, Richard Craig
title RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION
title_short RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION
title_full RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION
title_fullStr RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION
title_full_unstemmed RADIO FREQUENCY CONTROLLED STIMULATION OF INTRACELLULAR GOLD OR SILVER NANOPARTICLE CONJUGATES FOR USE AS POTENTIAL SENSORS OR MODULATORS OF BIOLOGICAL FUNCTION
title_sort radio frequency controlled stimulation of intracellular gold or silver nanoparticle conjugates for use as potential sensors or modulators of biological function
publisher Wright State University / OhioLINK
publishDate 2010
url http://rave.ohiolink.edu/etdc/view?acc_num=wright1277753458
work_keys_str_mv AT murdockrichardcraig radiofrequencycontrolledstimulationofintracellulargoldorsilvernanoparticleconjugatesforuseaspotentialsensorsormodulatorsofbiologicalfunction
_version_ 1719434060451807232

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