Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients

Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients

Bibliographic Details
Main Author: Atem, Jude N.
Language:English
Published: Wright State University / OhioLINK 2008
Subjects:
Biology
Microbiology
HIV-1
Eosinophils
HIV-1 infection of eosinophils
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=wright1208724964
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-wright12087249642021-08-03T06:16:44Z Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients Atem, Jude N. Biology Microbiology HIV-1 Eosinophils HIV-1 infection of eosinophils Eosinophils express membrane CD4 protein and can bind HIV-1 glycoprotein (gp) 120. Therefore, eosinophils could serve as host cells for HIV-1 infection in vivo, especially in the late phase of the infection. In culture, HIV-1 infects eosinophil precursors and primary eosinophils. Additionally HIV-1 proviral DNA sequences have been detected in the eosinophils of some HIV-1 positive patients. Since elevated levels of eosinophils occur during HIV-1 infection and parasitic infections, it implies that co-infection of parasites and HIV-1 could cause a much greater increase in the level of potential HIV-1 susceptible eosinophils. Therefore HIV-1 infection of eosinophils could partly explain the rapid spread of HIV-1 and the exacerbation of the disease especially in developing countries where HIV-1 and parasitic infections run concurrently. This study is a critical analysis of the current knowledge on HIV-1 infection of eosinophils focused on highlighting evidence that HIV-1 can productively infect mature human eosinophils in HIV/AIDS patients. 2008-05-30 English text Wright State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=wright1208724964 http://rave.ohiolink.edu/etdc/view?acc_num=wright1208724964 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
Microbiology
HIV-1
Eosinophils
HIV-1 infection of eosinophils
spellingShingle Biology
Microbiology
HIV-1
Eosinophils
HIV-1 infection of eosinophils
Atem, Jude N.
Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients
author Atem, Jude N.
author_facet Atem, Jude N.
author_sort Atem, Jude N.
title Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients
title_short Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients
title_full Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients
title_fullStr Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients
title_full_unstemmed Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients
title_sort human immunodeficiency virus-1 productively infects mature terminally differentiated eosinophils in hiv/aids patients
publisher Wright State University / OhioLINK
publishDate 2008
url http://rave.ohiolink.edu/etdc/view?acc_num=wright1208724964
work_keys_str_mv AT atemjuden humanimmunodeficiencyvirus1productivelyinfectsmatureterminallydifferentiatedeosinophilsinhivaidspatients
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