EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS
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| Language: | English |
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University of Cincinnati / OhioLINK
2000
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin974741712 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin9747417122021-08-03T06:15:48Z EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS Alasmi, Mahmood Mohamed Lipid metabolism Fractional Synthesis Rate Newborn Formula Breast (human) Milk Cholesterol metabolism in adults may be affected by cholesterol intake during infancy. Infants fed cow milk formula (CF) receive less cholesterol (1 - 3.5 mg/dl) than those fed human milk (HM, 10 -15 mg/dl). Infants fed soymilk formula receive no cholesterol. Cholesterol endogenous fractional synthesis rate (FSR) in infants is inversely related to dietary cholesterol intake. The purpose of this study is to test the following hypothesis: At four months of age, FSR of infants fed modified cow milk formula (MCF) [modified to contain cholesterol similar to amounts found in HM] will be similar to the FSR of infants who are HM fed, and will be less than the FSR of infants fed CF. This is a prospective, randomized double-masked study involving 39 full term infants followed until 4 months of age. Each Infant belonged to one of two formula-fed groups; CF (n=13) or MCF (n=10). A third group of HM-fed infants was not randomized or masked (n=16). FSR was measured as the rate of deuterium incorporation into erythrocyte membrane cholesterol. Serum lipid profile values were measured at four months of life. The data were analyzed using ANOVA. No differences were observed in serum HDL-cholesterol and triglycerides concentration among the three groups. Serum total cholesterol and LDL-cholesterol concentrations were higher in HM group (165.47 + 7.23 mg/dl and 85.0 + 7.72 mg/dl respectively), compared to CF group (139.42 + 8.08 mg/dl and 57.36 + 9.01 respectively). Infants fed MCF had an intermediate serum total-cholesterol and LDL-cholesterol concentration (148.20 + 8.85 mg/dl and 68.8 + 9.45 mg/dl, respectively). FSR was 3.8 fold lower in HM group (2.19 + 0.25 %/day) compared to FSR of infants fed either CF or MCF (p <0.0001). There was no significant difference in FSR between CF (8.58 + 0.30 %/day), and MCF (8.29 + 0.28 %/day). FSR was 3.8 fold higher in infants fed cow milk based formulas (regular and modified) vs. HM fed infants. Contrary to the hypothesis, cholesterol supplementation of one cow milk based formulation to HM levels (130 mg/dl) did not significantly reduce FSR at 4 months of age. 2000 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin974741712 http://rave.ohiolink.edu/etdc/view?acc_num=ucin974741712 restricted--full text not available online This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Lipid metabolism Fractional Synthesis Rate Newborn Formula Breast (human) Milk |
| spellingShingle |
Lipid metabolism Fractional Synthesis Rate Newborn Formula Breast (human) Milk Alasmi, Mahmood Mohamed EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS |
| author |
Alasmi, Mahmood Mohamed |
| author_facet |
Alasmi, Mahmood Mohamed |
| author_sort |
Alasmi, Mahmood Mohamed |
| title |
EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS |
| title_short |
EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS |
| title_full |
EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS |
| title_fullStr |
EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS |
| title_full_unstemmed |
EFFECTS OF CHOLESTEROL SUPPLEMENTATION ON CHOLESTEROL SYNTHESIS RATES IN INFANTS |
| title_sort |
effects of cholesterol supplementation on cholesterol synthesis rates in infants |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2000 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin974741712 |
| work_keys_str_mv |
AT alasmimahmoodmohamed effectsofcholesterolsupplementationoncholesterolsynthesisratesininfants |
| _version_ |
1719433707628003328 |