The Role of CD44 variant 9 in Gastric Ulcer Repair

The Role of CD44 variant 9 in Gastric Ulcer Repair

Bibliographic Details
Main Author: Teal, Emma L.
Language:English
Published: University of Cincinnati / OhioLINK 2019
Subjects:
Physiological Psychology
Gastric Ulcer Repair
CD44
Aging
Hedgehog
xCT
ROS
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563872522774123
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15638725227741232021-08-03T07:12:04Z The Role of CD44 variant 9 in Gastric Ulcer Repair Teal, Emma L. Physiological Psychology Gastric Ulcer Repair CD44 Aging Hedgehog xCT ROS Our goal is to understand the process of gastric epithelial repair after injury. Despite evidence showing that ulcers and subsequent complications are a burden that is focused in the elderly, there is a lack of knowledge as to the molecular mechanisms that disrupt normal repair even after H. pylori eradication. While it is established that the incidence of gastric ulcers in the elderly is primarily due to increased NSAID use and increased H. pylori infection, the tissue’s ability to repair gastric injuries is impaired. We have demonstrated that repair within the aged stomach is compromised whereby the gastric epithelium does not heal normally and exhibits abnormal cell composition post-repair. There are a number of mechanisms of action that may prevent the gastric mucosa from healing normally in response to injury, including decreased regenerative capacity suggesting changes in epithelial stem cells. 2019-10-14 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563872522774123 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563872522774123 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection NDLTD
language English
sources NDLTD
topic Physiological Psychology
Gastric Ulcer Repair
CD44
Aging
Hedgehog
xCT
ROS
spellingShingle Physiological Psychology
Gastric Ulcer Repair
CD44
Aging
Hedgehog
xCT
ROS
Teal, Emma L.
The Role of CD44 variant 9 in Gastric Ulcer Repair
author Teal, Emma L.
author_facet Teal, Emma L.
author_sort Teal, Emma L.
title The Role of CD44 variant 9 in Gastric Ulcer Repair
title_short The Role of CD44 variant 9 in Gastric Ulcer Repair
title_full The Role of CD44 variant 9 in Gastric Ulcer Repair
title_fullStr The Role of CD44 variant 9 in Gastric Ulcer Repair
title_full_unstemmed The Role of CD44 variant 9 in Gastric Ulcer Repair
title_sort role of cd44 variant 9 in gastric ulcer repair
publisher University of Cincinnati / OhioLINK
publishDate 2019
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563872522774123
work_keys_str_mv AT tealemmal theroleofcd44variant9ingastriculcerrepair
AT tealemmal roleofcd44variant9ingastriculcerrepair
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