The Role of RhoA in GPR116 Mediated Alveolar Homeostasis

The Role of RhoA in GPR116 Mediated Alveolar Homeostasis

Bibliographic Details
Main Author: Lawder, John J.
Language:English
Published: University of Cincinnati / OhioLINK 2019
Subjects:
Molecular Biology
RhoA
GPR116
Surfactant
GPCR
Lung
Actin
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563526829841322
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15635268298413222021-08-03T07:12:04Z The Role of RhoA in GPR116 Mediated Alveolar Homeostasis Lawder, John J. Molecular Biology RhoA GPR116 Surfactant GPCR Lung Actin GPR116 is an orphan adhesion GPCR (aGPCR) expressed primarily in alveolar type II (ATII) lung epithelial cells. Although the mechanism in unknown, GPR116 has been identified to regulate surfactant secretion and reabsorption through a Gaq effector protein. Being an orphan receptor, no known ligand has been identified for GPR116. However, a peptide coded from the Stachel sequence contained in the GAIN domain, specific to aGPCRs, can be used to activate the full-length receptor. Previous studies have linked GPR116 activation with an increase in Rho family GTPase activity and ultimately an increase in cytoskeletal structures in various cell types. While not well characterized, a similar increase in cortical F-actin has been observed following GPR116 activation in ATII cells as well. We hypothesize that the suppression of surfactant secretion mediated by GPR116 is a direct result of an increase in RhoA signaling leading to cortical F-actin stabilization. 2019-11-04 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563526829841322 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563526829841322 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Molecular Biology
RhoA
GPR116
Surfactant
GPCR
Lung
Actin
spellingShingle Molecular Biology
RhoA
GPR116
Surfactant
GPCR
Lung
Actin
Lawder, John J.
The Role of RhoA in GPR116 Mediated Alveolar Homeostasis
author Lawder, John J.
author_facet Lawder, John J.
author_sort Lawder, John J.
title The Role of RhoA in GPR116 Mediated Alveolar Homeostasis
title_short The Role of RhoA in GPR116 Mediated Alveolar Homeostasis
title_full The Role of RhoA in GPR116 Mediated Alveolar Homeostasis
title_fullStr The Role of RhoA in GPR116 Mediated Alveolar Homeostasis
title_full_unstemmed The Role of RhoA in GPR116 Mediated Alveolar Homeostasis
title_sort role of rhoa in gpr116 mediated alveolar homeostasis
publisher University of Cincinnati / OhioLINK
publishDate 2019
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563526829841322
work_keys_str_mv AT lawderjohnj theroleofrhoaingpr116mediatedalveolarhomeostasis
AT lawderjohnj roleofrhoaingpr116mediatedalveolarhomeostasis
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