Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis

Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis

Bibliographic Details
Main Author: Gulati, Ruhi
Language:English
Published: University of Cincinnati / OhioLINK 2019
Subjects:
Neurology
Epilepsy
mTOR hyperactivation
mTOR
stereotaxic surgery
PTEN
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15632738119463532021-08-03T07:11:54Z Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis Gulati, Ruhi Neurology Epilepsy mTOR hyperactivation mTOR stereotaxic surgery PTEN Epilepsy is a crippling neurological condition that is characterized by episodes of unprovoked seizures. Current antiepileptic drugs are effective at controlling seizures, but do not cure or modify the disease, and are ineffective for a third of the patient population with epilepsy. There are no clinically proven preventatives for patients at risk of developing epilepsy. The mTOR pathway has emerged as a promising new target as a disease-modifying therapy for epilepsy. Circumstantial evidence has linked mTOR to epileptogenesis through hyper activated signaling identified in acute seizures, status epilepticus, and traumatic brain injuries, yet the underlying mechanisms behind these effects remain unclear. mTOR signaling has been found to be dramatically increased in the dentate gyrus during temporal lobe epileptogenesis. The studies reported in this thesis look at the mTOR project from different projects: 1) Developing viral strategies to selectively delete mTOR from the Hippocampus and 2) Developing a model of Focal Cortical Dysplasia. 2019-11-04 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Neurology
Epilepsy
mTOR hyperactivation
mTOR
stereotaxic surgery
PTEN
spellingShingle Neurology
Epilepsy
mTOR hyperactivation
mTOR
stereotaxic surgery
PTEN
Gulati, Ruhi
Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis
author Gulati, Ruhi
author_facet Gulati, Ruhi
author_sort Gulati, Ruhi
title Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis
title_short Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis
title_full Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis
title_fullStr Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis
title_full_unstemmed Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis
title_sort developing viral strategies to study mtor and its regulators as mediators of epileptogenesis
publisher University of Cincinnati / OhioLINK
publishDate 2019
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353
work_keys_str_mv AT gulatiruhi developingviralstrategiestostudymtoranditsregulatorsasmediatorsofepileptogenesis
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