Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat

Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat

Bibliographic Details
Main Author: Schappacher, Katie
Language:English
Published: University of Cincinnati / OhioLINK 2019
Subjects:
Neurology
Chemotherapy
Neuropathy
Pediatric
Pain
Development
Neonatal
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1559057677003753
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15590576770037532021-08-03T07:11:21Z Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat Schappacher, Katie Neurology Chemotherapy Neuropathy Pediatric Pain Development Neonatal Childhood Acute Lymphoblastic Leukemia (ALL) is the most common childhood malignancy in the United States, accounting for approximately 30% of pediatric cancer diagnoses each year. Over the past several decades, the 5-year survival rate for ALL has risen to nearly 90% due to incorporation of modern treatment protocols that employ vincristine (VNC) as the frontline antineoplastic agent. Unfortunately, such improved outcomes have drawbacks, as VNC, along with several other chemotherapeutic agents produce neurotoxic effects and can result in chemotherapy-induced peripheral neuropathy (CIPN) in patient populations of all ages. While CIPN has been well studied clinically and experimentally in adults, little is known about the consequences of chemotherapy exposure in early life. Given that childhood ALL diagnoses typically occur around 2-3 years of age, a time at which the developing nervous system may be differentially vulnerable to peripheral insults, this dissertation characterizes for the first time, a rodent model of pediatric vincristine-induced peripheral neuropathy. 2019-08-12 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1559057677003753 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1559057677003753 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Neurology
Chemotherapy
Neuropathy
Pediatric
Pain
Development
Neonatal
spellingShingle Neurology
Chemotherapy
Neuropathy
Pediatric
Pain
Development
Neonatal
Schappacher, Katie
Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat
author Schappacher, Katie
author_facet Schappacher, Katie
author_sort Schappacher, Katie
title Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat
title_short Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat
title_full Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat
title_fullStr Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat
title_full_unstemmed Effects of Neonatal Vincristine Administration on Pain Sensitivity and Nociceptive Processing in the Developing Rat
title_sort effects of neonatal vincristine administration on pain sensitivity and nociceptive processing in the developing rat
publisher University of Cincinnati / OhioLINK
publishDate 2019
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1559057677003753
work_keys_str_mv AT schappacherkatie effectsofneonatalvincristineadministrationonpainsensitivityandnociceptiveprocessinginthedevelopingrat
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