Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer

Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer

Bibliographic Details
Main Author: Henderson, Melissa
Language:English
Published: University of Cincinnati / OhioLINK 2019
Subjects:
Genetics
bilateral mastectomy
decision making
hereditary breast cancer
high risk breast surveillance
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554213725302437
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15542137253024372021-08-03T07:09:47Z Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer Henderson, Melissa Genetics bilateral mastectomy decision making hereditary breast cancer high risk breast surveillance Background: Limited information is known about how women with pathogenic variants (PV) in moderate-penetrance genes make decisions to manage their increased risk of breast cancer. This study analyzed factors which may impact medical management decision-making.Methods: Women with a PV in a moderate-penetrance gene associated with increased risk for breast cancer were identified from a Cincinnati Children’s Hospital Medical Center database. Semi-structured, qualitative interviews were conducted to analyze decision-making factors. Themes were developed using deductive codes based on previous literature and inductive codes based on interviewee responses.Results: The 16 participants (mean age=55.9 years) included 12 women with a diagnosis of breast cancer. Six women (37.5%) chose bilateral mastectomy and 10 women (62.5%) chose surveillance as management. Transcriptions contained 1006 quotes tagged with 49 codes (Cohen’s kappa=0.80) that revealed seven decision-making factor themes: physician opinions, family history, personal history, risk perception, sibling influence, autonomy, and insurance/finances. Physician opinion was the only factor present in all interviews that was reported to influence medical management decision-making.Conclusions: Several themes were consistent with prior BRCA1/BRCA2 research (family history, risk perception, sibling influence, physician opinions). Autonomy and insurance/finances were also important to the participants. Results indicate an opportunity for physicians to assess patient perceptions and experiences and use the information to engage their patients in a decision-making process. 2019-07-09 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554213725302437 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554213725302437 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Genetics
bilateral mastectomy
decision making
hereditary breast cancer
high risk breast surveillance
spellingShingle Genetics
bilateral mastectomy
decision making
hereditary breast cancer
high risk breast surveillance
Henderson, Melissa
Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer
author Henderson, Melissa
author_facet Henderson, Melissa
author_sort Henderson, Melissa
title Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer
title_short Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer
title_full Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer
title_fullStr Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer
title_full_unstemmed Patient-physician Dialogue Matters: Factors that Impact Medical Management Decisions among Women with Pathogenic Variants in Moderate-penetrance Genes Associated with Hereditary Breast Cancer
title_sort patient-physician dialogue matters: factors that impact medical management decisions among women with pathogenic variants in moderate-penetrance genes associated with hereditary breast cancer
publisher University of Cincinnati / OhioLINK
publishDate 2019
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554213725302437
work_keys_str_mv AT hendersonmelissa patientphysiciandialoguemattersfactorsthatimpactmedicalmanagementdecisionsamongwomenwithpathogenicvariantsinmoderatepenetrancegenesassociatedwithhereditarybreastcancer
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