Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication

Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication

Bibliographic Details
Main Author: Paruchuri, Sai Sameer
Language:English
Published: University of Cincinnati / OhioLINK 2018
Subjects:
Mechanical Engineering
High-intensity focused ultrasound
Magnetic nanoparticles
Enhanced heating
Attenuation coefficient
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1544000023895472
id ndltd-OhioLink-oai-etd.ohiolink.edu-ucin1544000023895472
record_format oai_dc
spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15440000238954722021-08-03T07:09:15Z Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication Paruchuri, Sai Sameer Mechanical Engineering High-intensity focused ultrasound Magnetic nanoparticles Enhanced heating Attenuation coefficient Background. Magnetic nanoparticles (mNPs) act as acoustic mediators during High-Intensity Focused Ultrasound (HIFU) therapy aiding in enhanced heating and prevention of collateral damage. Few researchers have presented the mechanism underlying enhanced heating due to the mNPs. Among several factors, the effect of enhanced heating may be attributed to the increase in overall attenuation coefficient (a) of tissue mimicking material (TMM) due to infusion of mNPs. This thesis presents an assessment of the variation in attenuation coefficient (a) of TMM and therefore, enhanced temperature rise due to addition of specific concentrations of mNPs.Methods. In vitro HIFU experiments and computations were performed for TMM infused with physiologically acceptable concentrations (0% - control, 0.047% - lower concentration and 0.2% - higher concentration) of mNPs at three input powers of 10, 15 and 20 W. After ensuring the validity of the computational methodology by comparison with experimental off-focal temperature rise measurements, the experimental and numerical approaches were integrated to assess the a of the TMM infused with mNPs. Subsequently, a correlation between a and mNP concentration was obtained.Results and conclusion. Among a total of 9 cases (3 concentrations × 3 powers), the percentage difference between experimental and numerical off-focal temperature rise was less than 20% for 8 cases. The percentage difference between experimentally-derived and numerical focal temperature rise was less than 15% for all the 9 cases. A 42% increase in a was obtained with addition of 0.2% w/V of mNPs. A linear increase in a with respect to mNP concentration was observed with an R^2 value of 0.99. It was concluded that the infusion of mNPs in tissues provides increased a leading to enhanced temperature rise during HIFU sonication. 2018 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1544000023895472 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1544000023895472 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Mechanical Engineering
High-intensity focused ultrasound
Magnetic nanoparticles
Enhanced heating
Attenuation coefficient
spellingShingle Mechanical Engineering
High-intensity focused ultrasound
Magnetic nanoparticles
Enhanced heating
Attenuation coefficient
Paruchuri, Sai Sameer
Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication
author Paruchuri, Sai Sameer
author_facet Paruchuri, Sai Sameer
author_sort Paruchuri, Sai Sameer
title Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication
title_short Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication
title_full Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication
title_fullStr Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication
title_full_unstemmed Assessing Factors Influencing Temperature Rise in Magnetic Nanoparticle Infused Tissue Mimicking Material During High Intensity Focused Ultrasound Sonication
title_sort assessing factors influencing temperature rise in magnetic nanoparticle infused tissue mimicking material during high intensity focused ultrasound sonication
publisher University of Cincinnati / OhioLINK
publishDate 2018
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1544000023895472
work_keys_str_mv AT paruchurisaisameer assessingfactorsinfluencingtemperatureriseinmagneticnanoparticleinfusedtissuemimickingmaterialduringhighintensityfocusedultrasoundsonication
_version_ 1719455044954226688

Similar Items