Numerical Simulation and Graphical Illustration of Ionization by Charged Particles as a Tool toward Understanding Biological Effects of Ionizing Radiation
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University of Cincinnati / OhioLINK
2018
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535381068931831 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15353810689318312021-08-03T07:08:29Z Numerical Simulation and Graphical Illustration of Ionization by Charged Particles as a Tool toward Understanding Biological Effects of Ionizing Radiation Mahee, Durude Physics biological effects of ionizing radiation LET and biological effects DNA double strand breaks track model This thesis presents the numerical simulation and 3D representation of the “track model” [1, 2], a statistical ionization model developed to describe the ionization distribution at sub-molecular level in biological materials by energetic charged particles. The track model is based on the theory of stopping power [3] and is used to calculate the rates of clustered ionization in DNA. In the numerical simulations, ionization patterns from charged particles are shown for three different levels of linear energy transfer (LET) - Low, medium (10 times Low-LET) and high (100 times Low-LET), corresponding to 1 Gray (Gy) radiation dose for different charged particles. For the graphical visualizations, human DNA genome is represented as cubic cells and the clustered ionization is shown as cluster of holes (created by the ionization) on linear tracks. All holes occurring on the same track within a 3 nm radius is considered to form a cluster. The visualization shows how the clustered ionization depends on LET and the probability of occurrence of clusters with higher complexity (defined as the number of holes in a cluster) increases from low to higher LET radiation. 2018 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535381068931831 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535381068931831 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Physics biological effects of ionizing radiation LET and biological effects DNA double strand breaks track model |
| spellingShingle |
Physics biological effects of ionizing radiation LET and biological effects DNA double strand breaks track model Mahee, Durude Numerical Simulation and Graphical Illustration of Ionization by Charged Particles as a Tool toward Understanding Biological Effects of Ionizing Radiation |
| author |
Mahee, Durude |
| author_facet |
Mahee, Durude |
| author_sort |
Mahee, Durude |
| title |
Numerical Simulation and Graphical Illustration of Ionization by Charged Particles as a Tool toward Understanding Biological Effects of Ionizing Radiation |
| title_short |
Numerical Simulation and Graphical Illustration of Ionization by Charged Particles as a Tool toward Understanding Biological Effects of Ionizing Radiation |
| title_full |
Numerical Simulation and Graphical Illustration of Ionization by Charged Particles as a Tool toward Understanding Biological Effects of Ionizing Radiation |
| title_fullStr |
Numerical Simulation and Graphical Illustration of Ionization by Charged Particles as a Tool toward Understanding Biological Effects of Ionizing Radiation |
| title_full_unstemmed |
Numerical Simulation and Graphical Illustration of Ionization by Charged Particles as a Tool toward Understanding Biological Effects of Ionizing Radiation |
| title_sort |
numerical simulation and graphical illustration of ionization by charged particles as a tool toward understanding biological effects of ionizing radiation |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2018 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535381068931831 |
| work_keys_str_mv |
AT maheedurude numericalsimulationandgraphicalillustrationofionizationbychargedparticlesasatooltowardunderstandingbiologicaleffectsofionizingradiation |
| _version_ |
1719454592372047872 |