An Integrated System for Sweat Stimulation, Sampling and Sensing
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University of Cincinnati / OhioLINK
2018
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535371796736114 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15353717967361142021-08-03T07:08:18Z An Integrated System for Sweat Stimulation, Sampling and Sensing Hauke, Adam J. Biomedical Research sweat sensing pharmacology nanofluididc wearable health monitoring point of care iontophoresis As point-of-care technology continues to evolve, more research efforts are focusing on wearable health monitoring devices. Wearables grant unprecedented potential to continuously monitor vast amounts of vital information about a user’s well-being and do so without need for the attention of the wearer or trained personnel. To achieve such a device, developers have been striving to find solutions that offer non-invasive interrogation techniques while still providing access to core physiological information. Recent advances in sweat sensing research strongly meet these criteria and place it on the forefront of the wearables field. Technology developed in these efforts has matured to the verge of realizing an all-in-one system. Upon creation of a few remaining components, all that remains is custom integration of the new and existing technology to produce a high-quality, first generation complete sweat sensing system.In this dissertation, the current status of sweat sensing is first reviewed and the remaining challenges are analyzed to identify handling of ultra-low sample volumes as the core problem. Solutions to this problem are explored through research and experimentation. Improving the low volume sample capabilities of some existing electrode sensor platforms fabrication are first investigated. Next, a novel fluid sampling and transport device with specific advantages to handling nL scale sample volumes is theorized. Demonstration of the sample management device revealed it as the strongest possible candidate to complete integration of the key components needed for a wearable sweat system. Proceeding with this foundation, the new device was then used to integrate a recent breakthrough in wearable iontophoretic sweat stimulation with a biosensor and demonstrated to provide continuous long-term biomarker monitoring in a human subjects study. This system is further validated as a commercially relevant strategy, owing to its versatile design which is modular, made of low-cost materials, and fabricated in a mass manufacturable assembly. These developments present wearable designers with a new benchmark to build upon in proceeding to push sweat sensing toward the next generation of wearable health monitoring. 2018-10-11 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535371796736114 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535371796736114 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomedical Research sweat sensing pharmacology nanofluididc wearable health monitoring point of care iontophoresis |
| spellingShingle |
Biomedical Research sweat sensing pharmacology nanofluididc wearable health monitoring point of care iontophoresis Hauke, Adam J. An Integrated System for Sweat Stimulation, Sampling and Sensing |
| author |
Hauke, Adam J. |
| author_facet |
Hauke, Adam J. |
| author_sort |
Hauke, Adam J. |
| title |
An Integrated System for Sweat Stimulation, Sampling and Sensing |
| title_short |
An Integrated System for Sweat Stimulation, Sampling and Sensing |
| title_full |
An Integrated System for Sweat Stimulation, Sampling and Sensing |
| title_fullStr |
An Integrated System for Sweat Stimulation, Sampling and Sensing |
| title_full_unstemmed |
An Integrated System for Sweat Stimulation, Sampling and Sensing |
| title_sort |
integrated system for sweat stimulation, sampling and sensing |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2018 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535371796736114 |
| work_keys_str_mv |
AT haukeadamj anintegratedsystemforsweatstimulationsamplingandsensing AT haukeadamj integratedsystemforsweatstimulationsamplingandsensing |
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1719454576817471488 |