Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function

Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function

Bibliographic Details
Main Author: Jones, Rebecca
Language:English
Published: University of Cincinnati / OhioLINK 2018
Subjects:
Toxicology
Endometriosis
Endocrine Disrupting Chemicals
Ovary
Hormones
Steroidegenesis
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1523635547444359
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15236355474443592021-08-03T07:06:04Z Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function Jones, Rebecca Toxicology Endometriosis Endocrine Disrupting Chemicals Ovary Hormones Steroidegenesis Endometriosis is a gynecological disease affecting 1 in 10 women of reproductive age. Endometriosis incidence has risen; however, whether this is due to disease awareness or environmental contamination is not understood. Our objective was to determine if Bisphenol A (BPA) or Bisphenol AF (BPAF) potentiate the development of endometriosis and if hormonal status plays a role in how toxicant exposure affects disease. A mouse model of endometriosis, where minced uterine tissue is injected into the peritoneal cavity of a host mouse, was used to examine the effects of BPA or BPAF on endometriosis in ovariectomized and hormonally intact mice. BPA or BPAF were delivered through diet to include no-observed-adverse-effect-level (NOAEL) and the low-observed-adverse-effect-level (LOAEL) exposure levels. After six weeks, endometriosis lesions, uteri, and ovaries in intact mice were collected. Lesion weight, lesion volume, lesion and uterine proliferation, lesion and uterine apoptosis, lesion gene expression analysis, and ovarian histology and gene expression were examined to assess the effects of BPA and BPAF. In BPA and BPAF treatment groups, depending on dose and hormonal status, BPA and BPAF increase endometriosis lesion growth, and lesion and uterine proliferation. Gene expression changes in endometriosis lesions after BPA and BPAF treatment are dependent on hormonal status. BPAF, more so than BPA, increases endometriosis lesion growth. BPA and BPAF have the ability to potentiate endometriosis in intact mice, specifically increasing distal lesion volume. BPA and BPAF treatment disrupt normal ovarian follicle growth and function. While BPAF is being used as a substitute in place of BPA, BPAF appears to be similar, if not more estrogenic than BPA, and may be impacting the environmental contribution of the increased incidence of endometriosis. 2018-09-21 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1523635547444359 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1523635547444359 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Toxicology
Endometriosis
Endocrine Disrupting Chemicals
Ovary
Hormones
Steroidegenesis
spellingShingle Toxicology
Endometriosis
Endocrine Disrupting Chemicals
Ovary
Hormones
Steroidegenesis
Jones, Rebecca
Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function
author Jones, Rebecca
author_facet Jones, Rebecca
author_sort Jones, Rebecca
title Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function
title_short Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function
title_full Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function
title_fullStr Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function
title_full_unstemmed Bisphenol A and Bisphenol AF Potentiate Endometriosis Differently Based on Hormonal Status in Female Mice and Disrupt Normal Ovarian Function
title_sort bisphenol a and bisphenol af potentiate endometriosis differently based on hormonal status in female mice and disrupt normal ovarian function
publisher University of Cincinnati / OhioLINK
publishDate 2018
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1523635547444359
work_keys_str_mv AT jonesrebecca bisphenolaandbisphenolafpotentiateendometriosisdifferentlybasedonhormonalstatusinfemalemiceanddisruptnormalovarianfunction
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