Use of Silicone Adhesive for Improving Oral Controlled Delivery

Use of Silicone Adhesive for Improving Oral Controlled Delivery

Bibliographic Details
Main Author: Tolia, Gaurav
Language:English
Published: University of Cincinnati / OhioLINK 2018
Subjects:
Pharmaceuticals
Controlled release
Drug delivery
Silicone polymer
Drug release
Matrix tablet
Polymer properties
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521190743860228
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15211907438602282021-08-03T07:05:31Z Use of Silicone Adhesive for Improving Oral Controlled Delivery Tolia, Gaurav Pharmaceuticals Controlled release Drug delivery Silicone polymer Drug release Matrix tablet Polymer properties Controlled release oral dosage form offers great advantages over conventional dosage form by providing steady drug plasma concentration, decreasing the frequency of administration, and providing enhanced patient compliance. However, orally ingested tablet is exposed to varying pH conditions and fluctuating mechanical agitations during its travel through the gastrointestinal tract (GIT). Selection of materials that provide controlled release mechanism to the oral dosage form is important as they can a) minimize drug release rate fluctuations for ionizable drugs during its travel along the changing pH environment of the GIT and b) maintain the release rate mechanism even when subjected to the physiological mechanical agitation forces. To examine these two important requirements, matrix tablets prepared using low glass transition temperature (Tg) silicone pressure sensitive adhesive (PSA) were evaluated and compared with matrix tablets prepared using high Tg ethyl cellulose (EC). Specifically, the effect of dissolution medium pH on drug release from binary tablets consisting of the polymer and ionizable model drugs verapamil hydrochloride and diclofenac sodium was studied using USP dissolution apparatus (without mechanical stress). The effect of simulated physiological mechanical stress agitation on drug release was studied using dissolution stress test apparatus for non-ionizable model drug acetaminophen. Mechanical properties, physical structures, electrical resistance, water uptake, and contact angle of pure polymer films and of matrix tablets were studied to understand the relationships of these factors to drug release. Our study indicated that increasing polymer amount decreased drug release rate from both silicone PSA and EC tablets using USP dissolution apparatus. However, silicone PSA tablets showed lower friability compared to EC tablets. The application of physiological simulated mechanical stress affected drug release from high Tg EC tablets that resulted in burst release of acetaminophen whereas silicone PSA tablets were resistant to the mechanical effect. Rate and extent of water uptake into matrix tablets during drug release experiments were related to polymer compressibility properties. In addition, tablet water uptake on exposure to dissolution medium correlated to the mechanical properties of the polymer. Highly compressible silicone PSA showed lower water uptake and higher electrical resistance compared to EC tablets. Silicone PSA matrix tablets showed pH-independent release of verapamil HCl. However, EC matrix tablet of verapamil HCl did not show pH-independent release. EC matrix tablets also showed larger difference in drug release compared to silicone PSA matrix for weakly acidic model drug diclofenac sodium when exposed to acid dissolution medium. Silicone PSA provides both mechanical and electrical resistance properties which may be important in choosing a polymer for oral matrix tablets. The results suggest that silicone PSA is a promising excipient for oral controlled release to minimize the effect of mechanical agitation and dissolution medium pH on drug release. 2018-08-28 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521190743860228 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521190743860228 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Pharmaceuticals
Controlled release
Drug delivery
Silicone polymer
Drug release
Matrix tablet
Polymer properties
spellingShingle Pharmaceuticals
Controlled release
Drug delivery
Silicone polymer
Drug release
Matrix tablet
Polymer properties
Tolia, Gaurav
Use of Silicone Adhesive for Improving Oral Controlled Delivery
author Tolia, Gaurav
author_facet Tolia, Gaurav
author_sort Tolia, Gaurav
title Use of Silicone Adhesive for Improving Oral Controlled Delivery
title_short Use of Silicone Adhesive for Improving Oral Controlled Delivery
title_full Use of Silicone Adhesive for Improving Oral Controlled Delivery
title_fullStr Use of Silicone Adhesive for Improving Oral Controlled Delivery
title_full_unstemmed Use of Silicone Adhesive for Improving Oral Controlled Delivery
title_sort use of silicone adhesive for improving oral controlled delivery
publisher University of Cincinnati / OhioLINK
publishDate 2018
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521190743860228
work_keys_str_mv AT toliagaurav useofsiliconeadhesiveforimprovingoralcontrolleddelivery
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