Role of Cell Membrane Permeability Barrier in Biodegradation Rates of Organic Compounds
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University of Cincinnati / OhioLINK
2017
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491813027417726 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin14918130274177262021-08-03T07:01:32Z Role of Cell Membrane Permeability Barrier in Biodegradation Rates of Organic Compounds Shrestha, Ankurman Chemical Engineering Biodegradation Cell Membrane Membrane Permeability Biodegradation Kinetics Limiting Step Mechanistic Model The role of cell membrane permeability in the biodegradation of organic compounds has been investigated in the present research study. A mechanistic model has been developed that explains the overall biodegradation process as the sum total of three phases: (1) molecular diffusion of the chemical from the bulk liquid phase, through the liquid-phase boundary layer, to the surface of the cell membrane; (2) diffusion of the chemical through the cell membrane; and (3) biotransformation of the chemical through a sequential, enzyme-based kinetic reactions. The biodegradation kinetics data of an exhaustive list of over 500 chemicals has been presented. For the first time, the cell membrane permeability rate and the bulk transport rate contribution towards the overall biodegradation rate has been shown in this study. The rate limiting step in the overall biodegradation process is determined using non-linear regression and correlation analysis. The overall biodegradation rate of randomly selected 50 chemicals was then predicted using the correlation findings. The present study concludes that the diffusion of the chemical through the cell membrane is the rate determining step in the overall biodegradation process. This sheds new light into the field of biodegradation and how researchers could use it to potentially enhance the biodegradation rates by altering the cell membrane permeability and also predict rates to take careful decisions towards the manufacturing of new chemicals. 2017 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491813027417726 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491813027417726 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Chemical Engineering Biodegradation Cell Membrane Membrane Permeability Biodegradation Kinetics Limiting Step Mechanistic Model |
| spellingShingle |
Chemical Engineering Biodegradation Cell Membrane Membrane Permeability Biodegradation Kinetics Limiting Step Mechanistic Model Shrestha, Ankurman Role of Cell Membrane Permeability Barrier in Biodegradation Rates of Organic Compounds |
| author |
Shrestha, Ankurman |
| author_facet |
Shrestha, Ankurman |
| author_sort |
Shrestha, Ankurman |
| title |
Role of Cell Membrane Permeability Barrier in Biodegradation Rates of Organic Compounds |
| title_short |
Role of Cell Membrane Permeability Barrier in Biodegradation Rates of Organic Compounds |
| title_full |
Role of Cell Membrane Permeability Barrier in Biodegradation Rates of Organic Compounds |
| title_fullStr |
Role of Cell Membrane Permeability Barrier in Biodegradation Rates of Organic Compounds |
| title_full_unstemmed |
Role of Cell Membrane Permeability Barrier in Biodegradation Rates of Organic Compounds |
| title_sort |
role of cell membrane permeability barrier in biodegradation rates of organic compounds |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2017 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491813027417726 |
| work_keys_str_mv |
AT shresthaankurman roleofcellmembranepermeabilitybarrierinbiodegradationratesoforganiccompounds |
| _version_ |
1719452132389683200 |