Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy

Bibliographic Details
Main Author:	Collier, Jason L.
Language:	English
Published:	University of Cincinnati / OhioLINK 2016
Subjects:	Mechanical Engineering in vivo measurement 131i-MIBG health physics technician
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460729902

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-ucin14607299022021-08-03T06:35:45Z Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy Collier, Jason L. Mechanical Engineering in vivo measurement 131i-MIBG health physics technician <sup>131</sup> I-metaiodobenzylguanidine, <sup>131</sup> I-MIBG, has increasingly been used as an effective radiotherapeutic agent for pediatric patients diagnosed with neuroblastoma. While not a cure, the agent allows patients the possibility of controlling their disease and lengthening disease stabilization. Radioiodine pharmaceuticals were reformulated in 1979 to reduce exposure to those attending to the patient by reducing the volatility of the iodine and increasing the use of encapsulation to limit the quantity of unbound radioiodine. However, therapeutic <sup>131</sup> I-MIBG may still be administered to the patient through a liquid form. Health physics technicians are responsible for ensuring regulatory compliance and safety in and around the patient’s room. This study was performed to determine if the health physics technicians were exposed to<sup> 131</sup> I while performing required tasks within the patient’s treatment room. Results showed that per therapeutic treatment, the health physics technicians were exposed to an average of 6.9x10<sup>-1</sup> µSv hr<sup>-1</sup>GBq. Furthermore, trace contaminate levels of <sup>131</sup> I were detected by direct, in vivo measurement in persons having a normal and hypoactive thyroid. In vivo measurements were performed using a single 2900 mm <sup>2</sup> high resolution germanium detector positioned approximately 3 cm from the thyroid while the subject was seated in a shielded room. The thyroid activity measured in the technicians was well below requirements for monitoring established by the U.S. Nuclear Regulatory Commission. Established methods and working conditions are adequate to insure that radiation exposure to health physics technicians supporting the<sup> 131</sup> I-MIBG radioiodine therapeutic procedures are consistent with the program to keep exposure as low as reasonably achievable. 2016-06-07 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460729902 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460729902 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Mechanical Engineering in vivo measurement 131i-MIBG health physics technician
spellingShingle	Mechanical Engineering in vivo measurement 131i-MIBG health physics technician Collier, Jason L. Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy
author	Collier, Jason L.
author_facet	Collier, Jason L.
author_sort	Collier, Jason L.
title	Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy
title_short	Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy
title_full	Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy
title_fullStr	Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy
title_full_unstemmed	Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy
title_sort	uptake and exposure measurements in health physics technicians associated with 131i-mibg patient therapy
publisher	University of Cincinnati / OhioLINK
publishDate	2016
url	http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460729902
work_keys_str_mv	AT collierjasonl uptakeandexposuremeasurementsinhealthphysicstechniciansassociatedwith131imibgpatienttherapy
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Uptake and Exposure Measurements in Health Physics Technicians Associated with 131I-MIBG Patient Therapy

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