Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments

Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments

Bibliographic Details
Main Author: Sonoda, Samantha
Language:English
Published: University of Cincinnati / OhioLINK 2015
Subjects:
Epidemiology
nitrates
urine
plasma
NHANES
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427883298
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin14278832982021-08-03T06:29:33Z Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments Sonoda, Samantha Epidemiology nitrates urine plasma NHANES Objectives: To determine the impact of dietary nitrate on circulating nitrate levels and to compare the potential biases between urinary nitrate and plasma nitrate measures in order to evaluate the impact of nitrate exposure on disease outcomes in future epidemiologic studies.Methods: Dietary data collected from 24-hr recalls and Food Frequency Questionnaires, urinary nitrate levels, and plasma nitrate levels from the National Health and Nutrition Examination Survey (NHANES) were analyzed using linear regression and multivariate regression models. Results from the NHANES analyses were compared to plasma nitrate analyses of the Health Professionals Follow-up Study (HPFS) performed by our group previously. Results: Both usual and acute intake of vegetables can significantly increase urinary nitrate levels (26% -33% increase of urinary nitrate with increased intake of vegetables from quintile 1 to quintile 5). Recent intake of red and processed meat does not decrease urinary nitrate levels. Usual intakes of red and processed meat significantly reduce levels of urinary nitrate (8% reduction using averaged 24-hr recalls and 16% reduction using non-quantitative FFQ with increased intake of red and processed meat from quintile 1 to quintile 5). The associations of vegetables and red and processed meat with urinary nitrate in the NHANES cohort are very similar to the associations of these foods with plasma nitrate observed in the HPFS cohort. Conclusions: In summary, urinary nitrate is a valid measurement for assessing vegetable and red and processed meat impact on circulating nitrate levels and is consistent with results using plasma nitrate measurement. 2015-09-01 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427883298 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427883298 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection NDLTD
language English
sources NDLTD
topic Epidemiology
nitrates
urine
plasma
NHANES
spellingShingle Epidemiology
nitrates
urine
plasma
NHANES
Sonoda, Samantha
Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments
author Sonoda, Samantha
author_facet Sonoda, Samantha
author_sort Sonoda, Samantha
title Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments
title_short Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments
title_full Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments
title_fullStr Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments
title_full_unstemmed Usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments
title_sort usual and recent impact on circulating nitrate levels: comparison of different dietary assessment instruments
publisher University of Cincinnati / OhioLINK
publishDate 2015
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427883298
work_keys_str_mv AT sonodasamantha usualandrecentimpactoncirculatingnitratelevelscomparisonofdifferentdietaryassessmentinstruments
_version_ 1719437761927184384

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