The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups

Bibliographic Details
Main Author:	Zhou, Xinyao
Language:	English
Published:	University of Cincinnati / OhioLINK 2013
Subjects:	Nutrition Overweight Obese pregnancy DHA status Insulin sensitivity Race Ethnicity HOMA IR Adiponectin
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368085585

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-ucin13680855852021-08-03T05:23:42Z The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups Zhou, Xinyao Nutrition Overweight Obese pregnancy DHA status Insulin sensitivity Race Ethnicity HOMA IR Adiponectin Objective: To investigate the relationship between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in Non-Hispanic Black, Hispanic, or Non-Hispanic White overweight/obese pregnant women.Design and methods: This is a secondary analysis of data collected in a parallel, double-blind, placebo-controlled study investigating the effects of 10 weeks of docosahexaenoic acid (DHA) supplementation (800 mg DHA in algal oil from 26 to 36 weeks gestation) on insulin sensitivity and metabolic markers in overweight/obese pregnant women. Insulin sensitivity was measured after a 2-hour meal challenge at 36 weeks of pregnancy. The homeostasis model assessment of insulin resistance (HOMA-IR), muscle insulin sensitivity index (MISI), and the product of insulin1-30 [AUC]glucose1-30 [AUC], measured during the meal challenge, were calculated. Fasting plasma glucose, insulin, and adiponectin were measured at 36 weeks.Subjects: Healthy, English-speaking pregnant women (N=106), between the ages of 18-40 years, with a singleton pregnancy, a BMI >25 and < 60 kg/m2, and who had complete data, were included for this analysis. Subjects were recruited from the greater Cincinnati, OH region (Non-Hispanic Black and White) and San Antonio, TX (Hispanic White).Results: Hispanic women had significantly higher mean erythrocyte DHA (EDHA) concentrations than Non-Hispanic Black and White counterparts (p<0.001). There was no relationship between EDHA status, measured at 36 weeks gestation, and insulin sensitivity or resistance in any of the racial/ethnic groups of overweight/obese, pregnant women. However, there were racial/ethnic differences in measures of glucose metabolism. Being in the Non-Hispanic Black group explained 7.7% of the variance in fasting glucose concentration (p=0.005). Being in the Hispanic group explained 20.5% of the variance in fasting glucose concentration (p=0.000); 5.3% of the variance in fasting insulin concentration (p=0.022); and 9% of the variance in HOMA-IR (p=0.037). Being in the Non-Hispanic White group explained 4.2% of the variance in fasting insulin concentration (p=0.005) and 5.3% of the variance in HOMA-IR (p=0.022). Adiponectin was significantly, negatively correlated with HOMA-IR, fasting insulin concentration, and insulin1-30 [AUC]glucose1-30[AUC] and explained 10.30% of the variance in HOMA-IR, 4.75% of the variance in fasting insulin concentration, and 4.97% of the variance in insulin1-30[AUC]glucose1-30[AUC]. Adiponectin was significantly, positively correlated with MISI and it explained 3.84% of the variance in MISI.Conclusion: There was no relationship between EDHA status and insulin sensitivity in overweight/obese, pregnant women of different racial/ethnic groups (Non-Hispanic Black, Hispanic, and Non-Hispanic White). However, there were racial/ethnic differences in measures of glucose metabolism. Compared to Non-Hispanic Blacks and Whites, Hispanic women had significantly lower concentration of fasting glucose, fasting insulin, and HOMA-IR and significantly higher concentration of EDHA than the other 2 groups. Adiponectin was a predictor of insulin sensitivity estimated by HOMA-IR, fasting insulin, insulin1-30 [AUC]glucose1-30 [AUC], and MISI. 2013-10-14 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368085585 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368085585 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Nutrition Overweight Obese pregnancy DHA status Insulin sensitivity Race Ethnicity HOMA IR Adiponectin
spellingShingle	Nutrition Overweight Obese pregnancy DHA status Insulin sensitivity Race Ethnicity HOMA IR Adiponectin Zhou, Xinyao The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups
author	Zhou, Xinyao
author_facet	Zhou, Xinyao
author_sort	Zhou, Xinyao
title	The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups
title_short	The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups
title_full	The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups
title_fullStr	The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups
title_full_unstemmed	The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups
title_sort	association between erythrocyte docosahexaenoic acid (edha) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups
publisher	University of Cincinnati / OhioLINK
publishDate	2013
url	http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368085585
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The association between erythrocyte docosahexaenoic acid (EDHA) status and insulin sensitivity in overweight/obese pregnant women of different racial/ethnic groups

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