Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions
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| Language: | English |
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University of Cincinnati / OhioLINK
2012
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337351749 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin1337351749 |
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NDLTD |
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English |
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Analytical Chemistry Hydrogen Sensor Magnesium Biodegradable Metal Biomaterial Corrosion Biofouling |
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Analytical Chemistry Hydrogen Sensor Magnesium Biodegradable Metal Biomaterial Corrosion Biofouling Kuhlmann, Julia Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions |
| author |
Kuhlmann, Julia |
| author_facet |
Kuhlmann, Julia |
| author_sort |
Kuhlmann, Julia |
| title |
Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions |
| title_short |
Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions |
| title_full |
Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions |
| title_fullStr |
Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions |
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Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions |
| title_sort |
sensing as a tool to monitor magnesium based material corrosion in aqueous solutions |
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University of Cincinnati / OhioLINK |
| publishDate |
2012 |
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http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337351749 |
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AT kuhlmannjulia sensingasatooltomonitormagnesiumbasedmaterialcorrosioninaqueoussolutions |
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1719433594875674624 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin13373517492021-08-03T06:15:34Z Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions Kuhlmann, Julia Analytical Chemistry Hydrogen Sensor Magnesium Biodegradable Metal Biomaterial Corrosion Biofouling The NSF Generation-3 Engineering Research Center for Revolutionizing Metallic Biomaterials was launched in September 2008 and is formed by research groups at three national universities and one research group at the Hannover Medical School in Germany as a global partner. The ERC proposed “to develop the fundamental knowledge and technology needed to advance biocompatible and biodegradable metal-based (especially Mg) implantable systems with feedback control for reconstruction and regeneration”. More specifically these technologies will be used to develop craniofacial and orthopedic applications, cardiovascular and thoracic devices, and responsive biosensors and neural applications. Although metals have been used as internal fixtures to aid healing of fractured bones and tissue for more than 100 years, biodegradable metallic implant materials have gained increasing interest over the past years in the orthopedic and biomedical engineering field, as they exhibit unique properties that could potentially outperform currently used permanent implant materials. Today’s commonly used implant materials for orthopedic applications are stainless steel, titanium alloys and cobalt-chromium-based alloys, and are intended to permanently remain in the body unless they are removed by a secondary surgery. However, these materials have been reported to cause problems such as stress shielding or the release of toxic metal ions through corrosion, which can lead to infections or allergies. To develop biodegradable metallic implant materials, many researchers are focusing on magnesium and its alloys as their unique properties, which include physical and mechanical properties close to bone, make them promising candidates for biodegradable implants. Furthermore, these materials are generally non-toxic, lightweight and corrode rapidly in aqueous environments. During this corrosion, magnesium is oxidized to magnesium ions, as water is reduced to hydrogen and hydroxyl ions. The research presented here is mainly focused on the detection of hydrogen gas to assist in the analysis of the corrosion of magnesium and its alloys in aqueous solutions as well as in <i>in vitro</i> and <i>in vivo</i> systems. Different types of hydrogen sensors and commonly used hydrogen monitoring techniques used during magnesium corrosion are discussed. A novel and simple potentiometric hydrogen sensor was demonstrated and compared to a commercial amperometric hydrogen sensor to monitor dissolved hydrogen during magnesium alloy corrosion. This potentiometric sensor was integrated in an electrochemical corrosion characterization system to monitor the corrosion of magnesium samples in different aqueous solutions. The system was tested with three different aqueous solutions and showed that it added valuable information to common immersion corrosion tests. The corrosion characterization system was then partially transferred to static and dynamic <i>in vitro</i> systems to monitor the corrosion behavior of magnesium samples under cell culture conditions and in the presence of proteins. Through an <i>in vivo</i> study the hydrogen concentration and gas composition of subcutaneous gas cavities formed during magnesium alloy corrosion were measured, disproving a common misbelieve that these cavities only contain hydrogen gas. Finally, it was shown that potentiometric measurements are not as sensitive to biofouling as it would occur within hours after exposure to biological samples (e.g. cell culture media, serum) than voltammetric measurements. 2012-10-05 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337351749 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337351749 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |