Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort
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University of Cincinnati / OhioLINK
2011
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin13188625892021-08-03T06:15:05Z Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort Nehus, Edward J. Surgery chronic kidney disease cardiovascular disease inflammation pediatrics Resistin, a 12.5 kDa protein, is produced by inflammatory cells and is elevated in patients with chronic kidney disease (CKD). While resistin was initially thought to mediate insulin resistance, more recent attention has focused on its role in inflammation and cardiovascular disease. This cross-sectional study analyzes the association of serum resistin with clinical and demographic parameters in the CKiD cohort, a large cohort of pediatric patients with stage II-IV CKD. In univariate analyses, serum resistin levels correlated negatively with glomerular filtration rate (GFR, p < 0.01). Increased serum resistin levels were associated with elevation of inflammatory cytokines, including interleukin-6 (IL-6, p < 0.01), interleukin-10 (p < 0.01), and tumor necrosis factor-a (p < 0.01). Resistin was not associated with insulin resistance (p = 0.13) as assessed by the homeostasis model assessment of insulin resistance (HOMA-IR), although it was positively correlated with serum triglycerides (p < 0.01) and negatively correlated with high-density lipoprotein cholesterol (p < 0.01). In multivariate analysis, only GFR, IL-6, pubertal status, and HOMA-IR were significantly associated with serum resistin. HOMA-IR, however, was negatively correlated with serum resistin. This was an unexpected finding that demonstrated an association of serum resistin levels with improved insulin sensitivity. IL-6 was strongly associated with resistin in multivariate analysis, suggesting that resistin is involved in the inflammatory milieu present in CKD and therefore may represent a novel risk factor for cardiovascular disease. Future prospective data will be needed to evaluate the predictive value of resistin in cardiovascular morbidity in children with CKD. 2011 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Surgery chronic kidney disease cardiovascular disease inflammation pediatrics |
| spellingShingle |
Surgery chronic kidney disease cardiovascular disease inflammation pediatrics Nehus, Edward J. Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort |
| author |
Nehus, Edward J. |
| author_facet |
Nehus, Edward J. |
| author_sort |
Nehus, Edward J. |
| title |
Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort |
| title_short |
Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort |
| title_full |
Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort |
| title_fullStr |
Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort |
| title_full_unstemmed |
Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort |
| title_sort |
correlates of resistin in children with chronic kidney disease: the ckid cohort |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2011 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589 |
| work_keys_str_mv |
AT nehusedwardj correlatesofresistininchildrenwithchronickidneydiseasetheckidcohort |
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1719433476210425856 |