Effect of coronary collateral flow on diagnostic parameters: An In vitro study
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University of Cincinnati / OhioLINK
2009
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin12584736302021-08-03T06:13:37Z Effect of coronary collateral flow on diagnostic parameters: An In vitro study Peelukhana, Srikara Vishwanath Mechanical Engineering Coronary collateral flow Fractional flow reserve Pressure recovery coefficient Lesion flow coefficient Severity of blockages in the arteries of heart (Coronary stenosis) needs to be known for treatment of heart diseases. Visual techniques give an idea about the blockage, but they fail to quantify the severity of blockage, the flow obstruction and pressure variations caused (functional severity). So, functional severity of coronary stenosis is often assessed using diagnostic parameters. These parameters are evaluated from the combined pressure and/or flow measurements taken at the site of the stenosis. However, when there are interconnections between arteries supplying blood (functional collaterals) downstream to the stenosis, the coronary flow rate increases, and the pressure in the stenosed artery is altered. This effect of downstream collaterals on different diagnostic parameters is studied using a physiological representative in vitro flow loop, with a solution of glycerin and water mimicking the shear-thinning properties of blood.<p>The three diagnostic parameters tested are Fractional Flow Reserve (FFR), defined as the ratio of distal pressure and pressure proximal to the stenosis, Pressure Drop Coefficient (CDP) and Lesion Flow Coefficient (LFC), parameters that are formulated based on fluid dynamics involved in the stenosed artery. The latter two were discussed in recent publications by our group. They are evaluated for three different severities of stenosis and tested for possible misinterpretation in the presence of variable collateral flows: Maximum collateral flow, Intermediate collateral flow, and partially developed collateral flow. Pressure and flow measurements are taken without downstream collateral flow and for three different collateral flow developments mentioned above. The parameters are then calculated from these readings.</p><p>In the case of intermediate stenosis (80% area blockage), FFR and LFC increased from 0.74 to 0.77 and 0.58 to 0.62 respectively for no collateral to fully developed collateral flow. Also, CDP decreased from 47 to 42 for no collateral to fully developed collateral flow. These changes in diagnostic parameters might lead to erroneous postponement of coronary intervention. Thus, variability in diagnostic parameters for the same stenosis leads to misinterpretation of stenosis severity in the presence of operating downstream collaterals.</p> 2009 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1258473630 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1258473630 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Mechanical Engineering Coronary collateral flow Fractional flow reserve Pressure recovery coefficient Lesion flow coefficient |
| spellingShingle |
Mechanical Engineering Coronary collateral flow Fractional flow reserve Pressure recovery coefficient Lesion flow coefficient Peelukhana, Srikara Vishwanath Effect of coronary collateral flow on diagnostic parameters: An In vitro study |
| author |
Peelukhana, Srikara Vishwanath |
| author_facet |
Peelukhana, Srikara Vishwanath |
| author_sort |
Peelukhana, Srikara Vishwanath |
| title |
Effect of coronary collateral flow on diagnostic parameters: An In vitro study |
| title_short |
Effect of coronary collateral flow on diagnostic parameters: An In vitro study |
| title_full |
Effect of coronary collateral flow on diagnostic parameters: An In vitro study |
| title_fullStr |
Effect of coronary collateral flow on diagnostic parameters: An In vitro study |
| title_full_unstemmed |
Effect of coronary collateral flow on diagnostic parameters: An In vitro study |
| title_sort |
effect of coronary collateral flow on diagnostic parameters: an in vitro study |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2009 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1258473630 |
| work_keys_str_mv |
AT peelukhanasrikaravishwanath effectofcoronarycollateralflowondiagnosticparametersaninvitrostudy |
| _version_ |
1719433065921511424 |