The changes of antibody levels to MsgC variants over time in HIV-infected men

Bibliographic Details
Main Author:	Djawe, Kpandja
Language:	English
Published:	University of Cincinnati / OhioLINK 2008
Subjects:	Biomedical Research Immunology
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211893247

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-ucin12118932472021-08-03T06:12:38Z The changes of antibody levels to MsgC variants over time in HIV-infected men Djawe, Kpandja Biomedical Research Immunology The Major Surface Glycoprotein (Msg) is a crucial protein complex in Pneumocystis pathogenicity and is involved in host-organism interaction. Our objectives are to analyze the antibody responses to four MsgC clones in three patient groups and to determine the factors associated with PcP death. Tobit regression model was used to analyze the mean antibody differences. We found higher odds of antibodies rise to MsgC1, MsgC8, and MsgC9 if the first AIDS-defining disease was PcP versus others (OR [95%CI]: 6.2 [1.1-35.4], the same). The mean antibodies to MsgC8 at last clinic visit was significantly higher in PcP patients compared to colonized and non-colonized patients (11.0 vs 2.3, 2.6, respectively). PcP patients had a highly rate of previous PcP diagnoses (73%) compared to the other groups (43% each). Our results suggest that PcP death was associated with higher antibody levels to MsgC8, and previous episode of PcP. 2008-08-22 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211893247 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211893247 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Biomedical Research Immunology
spellingShingle	Biomedical Research Immunology Djawe, Kpandja The changes of antibody levels to MsgC variants over time in HIV-infected men
author	Djawe, Kpandja
author_facet	Djawe, Kpandja
author_sort	Djawe, Kpandja
title	The changes of antibody levels to MsgC variants over time in HIV-infected men
title_short	The changes of antibody levels to MsgC variants over time in HIV-infected men
title_full	The changes of antibody levels to MsgC variants over time in HIV-infected men
title_fullStr	The changes of antibody levels to MsgC variants over time in HIV-infected men
title_full_unstemmed	The changes of antibody levels to MsgC variants over time in HIV-infected men
title_sort	changes of antibody levels to msgc variants over time in hiv-infected men
publisher	University of Cincinnati / OhioLINK
publishDate	2008
url	http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211893247
work_keys_str_mv	AT djawekpandja thechangesofantibodylevelstomsgcvariantsovertimeinhivinfectedmen AT djawekpandja changesofantibodylevelstomsgcvariantsovertimeinhivinfectedmen
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The changes of antibody levels to MsgC variants over time in HIV-infected men

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