THE IN-VITRO EFFECTS OF ORGANIC SOLVENTS ON DERMAL ABSORPTION OF USED GASOLINE ENGINE OIL
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| Language: | English |
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University of Cincinnati / OhioLINK
2006
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155751513 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin11557515132021-08-03T06:11:26Z THE IN-VITRO EFFECTS OF ORGANIC SOLVENTS ON DERMAL ABSORPTION OF USED GASOLINE ENGINE OIL BROERING, PAUL FRANCIS, III A number of polycyclic aromatic hydrocarbons (PAHs) have a well-documented history of being animal carcinogens when these PAHs are applied to the skin of rats or mice. A number of governmental and international agencies have also listed these same PAHs as suspected human carcinogens. A commonly tested PAH mixture used for this research is used gasoline engine oil (UGEO). Talaska et al. (1999) have shown that kerosene can act to facilitate the absorption of UGEO through the skin and lead to increased DNA adducts in the lung. This study intends to determine whether other commonly used organic solvents will increase the passage of UGEO through the skin as well as re-confirming kerosene’s ability to facilitate UGEO through the skin. The study specifically analyzes the effects of gasoline, jet fuel (JP-8), and kerosene on UGEO absorption through cadaver skin. Franz cells will be used to create the in-vivo environment needed for this experiment. It is hypothesized that each of these organic solvents will also increase the permeation rate of UGEO through the skin. This is based on the knowledge of the similar chemical structures these organic solvents share with kerosene, which has already been identified as a UGEO facilitator through the skin. Data analysis will be performed via high pressure liquid chromatography (HPLC) to identify and quantify the PAHs that have permeated through the cadaver skin. This research is very important to the understanding of how certain solvents may facilitate the absorption of PAHs. It may lead to the use of PPE and the awareness of the dermal exposure dangers of certain combinations of compounds. Future studies need to be done to verify and confirm the results found from this pilot study. The safety of employees can not be based on a one time study but must be cross checked by a number of research facilities to better determine the most accurate data and the most effective means of protection for employees. Future studies also needs to accrue more data on DNA adduct levels in the lung and skin after dermal exposure to UGEO with these organic solvents, which is not evaluated in this study. 2006-09-28 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155751513 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155751513 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| author |
BROERING, PAUL FRANCIS, III |
| spellingShingle |
BROERING, PAUL FRANCIS, III THE IN-VITRO EFFECTS OF ORGANIC SOLVENTS ON DERMAL ABSORPTION OF USED GASOLINE ENGINE OIL |
| author_facet |
BROERING, PAUL FRANCIS, III |
| author_sort |
BROERING, PAUL FRANCIS, III |
| title |
THE IN-VITRO EFFECTS OF ORGANIC SOLVENTS ON DERMAL ABSORPTION OF USED GASOLINE ENGINE OIL |
| title_short |
THE IN-VITRO EFFECTS OF ORGANIC SOLVENTS ON DERMAL ABSORPTION OF USED GASOLINE ENGINE OIL |
| title_full |
THE IN-VITRO EFFECTS OF ORGANIC SOLVENTS ON DERMAL ABSORPTION OF USED GASOLINE ENGINE OIL |
| title_fullStr |
THE IN-VITRO EFFECTS OF ORGANIC SOLVENTS ON DERMAL ABSORPTION OF USED GASOLINE ENGINE OIL |
| title_full_unstemmed |
THE IN-VITRO EFFECTS OF ORGANIC SOLVENTS ON DERMAL ABSORPTION OF USED GASOLINE ENGINE OIL |
| title_sort |
in-vitro effects of organic solvents on dermal absorption of used gasoline engine oil |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2006 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155751513 |
| work_keys_str_mv |
AT broeringpaulfrancisiii theinvitroeffectsoforganicsolventsondermalabsorptionofusedgasolineengineoil AT broeringpaulfrancisiii invitroeffectsoforganicsolventsondermalabsorptionofusedgasolineengineoil |
| _version_ |
1719432440525619200 |