Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases

Bibliographic Details
Main Author:	Gopalakrishnan, Pradeep
Language:	English
Published:	University of Cincinnati / OhioLINK 2005
Subjects:	laser photocoagulation microphotocoagulation selective retinal treatment rate process analysis retinal pigment epithelium
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=ucin1121436799

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-ucin11214367992021-08-03T06:10:28Z Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases Gopalakrishnan, Pradeep laser photocoagulation microphotocoagulation selective retinal treatment rate process analysis retinal pigment epithelium Selective retinal photocoagulation uses short pulsed lasers to coagulate retinal pigment epithelium selectively, while sparing the photoreceptors. The problem associated with the usage of short pulsed laser is the difficulty in determining the correct dosimetry parameters. This study quantifies the influence of laser parameters and variation of thickness and melanin concentration of RPE over the therapeutic range. The laser-tissue interaction is numerically investigated by analyzing the transient temperature in ocular tissues during the treatment. The rate process analysis for thermal injury is employed to estimate the selective damage of retina. Calculated contours of Arrhenius integral show both the area and magnitude of damage caused by various laser parameters. Results reveal that the 2 micro-s pulsed-laser with green wavelength and Gaussian profile is more effective for selective retinal treatment. The repetition frequency of 100 Hz selectively damages RPE, while 1000 Hz produces damage to neural retina and choroid located within 2 micro-m from RPE interface. However, the maximum Arrhenius integral for 1000 Hz is ~2000 times greater than that for 100 Hz. The threshold energy required for 14 micro-m thick RPE is ~25% less than that for 10 micro-m RPE, while 6 micro-m RPE requires ~35% more energy. 2005-09-27 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1121436799 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1121436799 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	laser photocoagulation microphotocoagulation selective retinal treatment rate process analysis retinal pigment epithelium
spellingShingle	laser photocoagulation microphotocoagulation selective retinal treatment rate process analysis retinal pigment epithelium Gopalakrishnan, Pradeep Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases
author	Gopalakrishnan, Pradeep
author_facet	Gopalakrishnan, Pradeep
author_sort	Gopalakrishnan, Pradeep
title	Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases
title_short	Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases
title_full	Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases
title_fullStr	Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases
title_full_unstemmed	Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases
title_sort	influence of laser parameters on selective retinal photocoagulation for macular diseases
publisher	University of Cincinnati / OhioLINK
publishDate	2005
url	http://rave.ohiolink.edu/etdc/view?acc_num=ucin1121436799
work_keys_str_mv	AT gopalakrishnanpradeep influenceoflaserparametersonselectiveretinalphotocoagulationformaculardiseases
_version_	1719432148973256704

Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases

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