THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS

THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS

Bibliographic Details
Main Author: WOO, JESSICA GRAUS
Language:English
Published: University of Cincinnati / OhioLINK 2004
Subjects:
Adiponectin
Adolescent
Genetic
Obesity
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin11008088272021-08-03T06:10:00Z THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS WOO, JESSICA GRAUS Adiponectin Adolescent Genetic Obesity Obesity is increasingly prevalent among adolescents, and the health consequences of obesity are well-documented. Not all obese individuals experience metabolic dysfunction, possibly due to differences in adipocyte proteins, such as adiponectin. We know little about adiponectin in adolescence, when risks for metabolic disease are established. Therefore, we explored the relationships of demographic, developmental and metabolic traits with adiponectin levels, and associations between adiponectin gene variants, adiponectin levels and metabolic phenotypes in adolescents. We studied 1196 non-Hispanic white (NHW) and African-American (AA) adolescents in the Princeton City School District. In addition to existing data, including height, weight, waist circumference, puberty stage and blood lipids, insulin and glucose, we assayed plasma adiponectin and genotyped nine adiponectin gene variants. Insulin resistance was estimated using HOMA-IR. Adiponectin levels were higher in girls than boys, and higher in NHW than AA adolescents. Lean adolescents (BMI < 85%ile) had higher adiponectin levels than non-lean adolescents (BMI ≥ 85%ile). No sex differences were seen in pre-puberty, but boys’ levels were lower than girls’ in puberty and post-puberty. Adiponectin correlated negatively with body mass index (BMI) z-score, waist circumference, insulin, HOMA-IR, and triglycerides (TG), and positively with high-density lipoprotein (HDL) cholesterol. Correlations were significantly stronger among non-lean vs. lean adolescents for HOMA-IR, TG and HDL cholesterol, and interactions between adiponectin and BMI z-score were significant in models explaining HOMA-IR, HDL and TG. A haplotype in the adiponectin gene promoter (-11391, -10068 and -4521) was significantly associated with higher plasma adiponectin levels in NHW, but only marginally in AA. Surprisingly, this haplotype in NHW was also associated with lower HDL cholesterol and higher TG levels. In AA, haplotypes including variants from -10068 to +712 were independently associated with higher BMI z-score and TG. Sex and race differences in plasma adiponectin are established during puberty. Although adiponectin levels are lower among non-lean adolescents, the association with metabolic phenotypes increases with adiposity. Variants in the adiponectin gene influence adiponectin levels, adiposity and plasma lipid levels in a race-specific manner. Thus, adiponectin has a significant and changing role in adolescents’ metabolic phenotypes, and variants in the adiponectin gene contribute to these phenotypes. 2004 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Adiponectin
Adolescent
Genetic
Obesity
spellingShingle Adiponectin
Adolescent
Genetic
Obesity
WOO, JESSICA GRAUS
THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS
author WOO, JESSICA GRAUS
author_facet WOO, JESSICA GRAUS
author_sort WOO, JESSICA GRAUS
title THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS
title_short THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS
title_full THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS
title_fullStr THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS
title_full_unstemmed THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS
title_sort epidemiology of adiponectin during adolescence: demographic, developmental, metabolic and genetic associations
publisher University of Cincinnati / OhioLINK
publishDate 2004
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827
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AT woojessicagraus epidemiologyofadiponectinduringadolescencedemographicdevelopmentalmetabolicandgeneticassociations
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