DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY
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| Language: | English |
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University of Cincinnati / OhioLINK
2004
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085675249 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin10856752492021-08-03T06:09:46Z DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY NOEL, RICHARD JOSEPH eosinophil esophagitis pediatric allergy Hamilton Cincinnati Eosinophilic esophagitis (EE) refers to esophageal inflammation with marked tissue eosinophilia that does not respond to acid suppression therapy. Patients may have a variety of symptoms that mimic gastroesophageal reflux disease, but vomiting and dysphagia are the most common at presentation. We report on the descriptive epidemiology of a large population with EE. METHODS: With IRB approval, a clinical database was queried for patients with EE biopsy diagnosis, as defined as mucosal eosinophilia with >24 eosinophils per HPF, and proliferative changes with thickening of the basal layer and papillary lengthening. Date of the initial EE diagnosis, demographic information, and clinical information were recorded. Population data from the 2000 U.S. Census was obtained for incidence calculations in Hamilton County, Ohio, a population with a single pediatric hospital and pediatric GI practice. RESULTS: The search identified 315 subjects diagnosed between Feb. 1991 and Jan. 2004 from 25 states. Age at diagnosis was 8.9 +/- 6.1 years (mean +/- stdev) and the population was 72.2% male. Only 2.8% of cases were diagnosed prior to the year 2000. 103 subjects formed a subpopulation that resided within Hamilton County at the time of diagnosis. Two of these were diagnosed prior to 2000; the remainder has an age at diagnosis of 10.5 +/- 5.4 years (mean +/- stdev) and a male predominance (70.9%). Based on these data, the prevalence of EE in Hamilton County's pediatric population is 4 per 10,000 and the yearly incidence is approximately 1 in 10,000. The incidence has increased yearly between the years 2000-2003. CONCLUSIONS: The incidence of EE is approximately 1 per 10,000/yr and appears to be increasing in a single county. EE is an increasingly common disease and should be considered in the differential diagnosis of patients with GERD symptoms not responsive to acid suppression therapy. 2004-07-01 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085675249 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085675249 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
eosinophil esophagitis pediatric allergy Hamilton Cincinnati |
| spellingShingle |
eosinophil esophagitis pediatric allergy Hamilton Cincinnati NOEL, RICHARD JOSEPH DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY |
| author |
NOEL, RICHARD JOSEPH |
| author_facet |
NOEL, RICHARD JOSEPH |
| author_sort |
NOEL, RICHARD JOSEPH |
| title |
DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY |
| title_short |
DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY |
| title_full |
DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY |
| title_fullStr |
DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY |
| title_full_unstemmed |
DEMOGRAPHIC ANALYSIS OF ESOPHAGITIS: A POPULATION-BASED STUDY |
| title_sort |
demographic analysis of esophagitis: a population-based study |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2004 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085675249 |
| work_keys_str_mv |
AT noelrichardjoseph demographicanalysisofesophagitisapopulationbasedstudy |
| _version_ |
1719431930192068608 |