Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds

Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds

Bibliographic Details
Main Author: Offenbacher, Jennifer M.
Language:English
Published: University of Toledo / OhioLINK 2015
Subjects:
Chemistry
Pharmacy Sciences
Organic Chemistry
Analytical Chemistry
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-toledo14498282502021-08-03T06:34:36Z Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds Offenbacher, Jennifer M. Chemistry Pharmacy Sciences Organic Chemistry Analytical Chemistry Methuosis is a novel type of nonapoptic cell death in which vacuoles form and swell until the cell membrane bursts. Several indole-based chalcones have been found to induce methuosis. These indole-based chalcones contain a,ß-unsaturated ketones which may undergo Michael addition. However, the heterocycles on either side of the a,ß-unsaturated ketone have a less studied effect on Michael addition. Also, the metabolites of methuosis-inducing chalcones are reduced forms of the a,ß-unsaturated ketone. These metabolites are synthesized as a part of this thesis. Synthesis of analogues on the pyridinyl ring, primarily extending the nitrogen out of the ring and modifying the electronics is reported herein. 2015 English text University of Toledo / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250 http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Chemistry
Pharmacy Sciences
Organic Chemistry
Analytical Chemistry
spellingShingle Chemistry
Pharmacy Sciences
Organic Chemistry
Analytical Chemistry
Offenbacher, Jennifer M.
Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds
author Offenbacher, Jennifer M.
author_facet Offenbacher, Jennifer M.
author_sort Offenbacher, Jennifer M.
title Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds
title_short Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds
title_full Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds
title_fullStr Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds
title_full_unstemmed Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds
title_sort importance of the a,ß-unsaturated ketone in methuosis-inducing compounds
publisher University of Toledo / OhioLINK
publishDate 2015
url http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449828250
work_keys_str_mv AT offenbacherjenniferm importanceoftheaßunsaturatedketoneinmethuosisinducingcompounds
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