Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design

Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design

Bibliographic Details
Main Author: Hosseinipour, Milad
Language:English
Published: University of Toledo / OhioLINK 2013
Subjects:
Biomechanics
Biomedical Engineering
Biomedical Research
Engineering
Materials Science
Mechanical Engineering
Mechanics
Medical Imaging
Rehabilitation
Surgery
Therapy
Fluid Dynamics
heart
congestive heart failure
ventricular assistive device
ionic polymer metal composite
shape memory alloy
smart material
finite element analysis
CAD modeling
total artificial heart
actuator
experiment
hemodynamic
MRI
heart restraint method
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=toledo1372726495
id ndltd-OhioLink-oai-etd.ohiolink.edu-toledo1372726495
record_format oai_dc
collection NDLTD
language English
sources NDLTD
topic Biomechanics
Biomedical Engineering
Biomedical Research
Engineering
Materials Science
Mechanical Engineering
Mechanics
Medical Imaging
Rehabilitation
Surgery
Therapy
Fluid Dynamics
heart
congestive heart failure
ventricular assistive device
ionic polymer metal composite
shape memory alloy
smart material
finite element analysis
CAD modeling
total artificial heart
actuator
experiment
hemodynamic
MRI
heart restraint method
spellingShingle Biomechanics
Biomedical Engineering
Biomedical Research
Engineering
Materials Science
Mechanical Engineering
Mechanics
Medical Imaging
Rehabilitation
Surgery
Therapy
Fluid Dynamics
heart
congestive heart failure
ventricular assistive device
ionic polymer metal composite
shape memory alloy
smart material
finite element analysis
CAD modeling
total artificial heart
actuator
experiment
hemodynamic
MRI
heart restraint method
Hosseinipour, Milad
Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design
author Hosseinipour, Milad
author_facet Hosseinipour, Milad
author_sort Hosseinipour, Milad
title Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design
title_short Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design
title_full Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design
title_fullStr Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design
title_full_unstemmed Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design
title_sort design and development of an intra-ventricular assistive device for end stage congestive heart failure patients: conceptual design
publisher University of Toledo / OhioLINK
publishDate 2013
url http://rave.ohiolink.edu/etdc/view?acc_num=toledo1372726495
work_keys_str_mv AT hosseinipourmilad designanddevelopmentofanintraventricularassistivedeviceforendstagecongestiveheartfailurepatientsconceptualdesign
_version_ 1719419854733180928
spelling ndltd-OhioLink-oai-etd.ohiolink.edu-toledo13727264952021-08-03T05:24:22Z Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design Hosseinipour, Milad Biomechanics Biomedical Engineering Biomedical Research Engineering Materials Science Mechanical Engineering Mechanics Medical Imaging Rehabilitation Surgery Therapy Fluid Dynamics heart congestive heart failure ventricular assistive device ionic polymer metal composite shape memory alloy smart material finite element analysis CAD modeling total artificial heart actuator experiment hemodynamic MRI heart restraint method A novel intra-ventricular ventricular assistive device (VAD) for end stage heart failure patients is presented here. VADs are approved by FDA as Bridge to Transplantation Therapy, Bridge to Recovery Therapy and permanent or Destination Therapy for patients at NYHA Class IV level as an alternative to heart transplant. While all current devices need an open heart surgery, this new flexible structure enables a transcatheter implantation and therefore eliminates the thoracotomy. This also addresses the problem of anatomical fit for smaller adults and children, which is a limitation for many of the current VAD systems. Low energy consumption and similarity of the structure to currently available cardiac defibrillators makes the transcutaneous energy transmission (TET) possible, which reduces the possibility of infection significantly. Using flexible, biocompatible smart materials such as Ionic Conducting Polymer Metal Composites (IPMC) and Shape Memory Alloys (SMA) to actuate the device reduces the number of mechanical parts implanted. Compared with other ventricular assistive devices or total artificial hearts the absence of pistons, impellers, bearings, housings, bladders and valves makes the manufacturing, inspection and maintenance processes much simpler. The device will also reduce the risk of calcification, wearing out or other mechanical failures. Moreover, by mimicking natural motion of the heart, the device exerts almost no shear stress on blood cells and leaves no stagnant points, hence reduces the risk of hemolysis and thrombosis.Actuators, sensors, driveline, and drive unit are the main parts of the device. The actuator sits at the bottom of the ventricle and replicates the motion of the heart by squeezing and upward-downward motion. It may perform one or both of the motions based on the level of assistance needed. Different combinations of these motion mechanisms provide high, medium or low level of pressure increment and volume displacement based on the physiological needs and dependency of the patient on mechanical circulatory support system. Currently available VADs are riddled with many issues. A comprehensive review was performed on all available total artificial hearts, ventricular assistive devices and heart restraint methods. Advantages and disadvantages of each device were investigated. Since a precise model representing the non-geometric inner shape of the ventricle is essential for predicting the working environment and space limitations, a 3D CAD model was extracted from MRI of a real subject. Hemodynamics of an eligible patient was then examined to define the average working conditions and physiological needs. Next, different motion mechanisms were evaluated to find the one with maximum volume displacement, mimicking natural motion of the heart. Several actuators and actuation mechanisms using novel actuation materials were then studied. Different possible designs for actuators were then introduced to represent the possibility of utilizing active materials to perform desired motions and address the cardiac insufficiency. A combination of IPMCs and SMAs was chosen as the actuation mechanism.As the preliminary evaluation of the device, FE solution of the governing differential equation of the electrochemical-mechanical behavior of IPMCs was used to check the compliancy of IPMCs with those needs defined by hemodynamics and motion analyses. One-dimensional results of the FEM solution were extended to 2D to find the tip displacement of a flap IPMC actuator and were then experimentally verified. Finally, actuator embodiments were validated by FEA on Shape Memory Alloy actuators. 2013-11-27 English text University of Toledo / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=toledo1372726495 http://rave.ohiolink.edu/etdc/view?acc_num=toledo1372726495 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.

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