Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans

Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans

Bibliographic Details
Main Author: Wragg, Rachel T.
Language:English
Published: University of Toledo / OhioLINK 2010
Subjects:
Biology
monoamines
neuropeptides
chemosensation
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279208105
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-toledo12792081052021-08-03T06:07:48Z Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans Wragg, Rachel T. Biology monoamines neuropeptides chemosensation Monoamines and peptides modulate neuronal plasticity and interact to define behavioral state. However, little is known about specific interactions between monoaminergic and peptidergic signaling due in large part to the complexity of the mammalian nervous system. Therefore, we have examined the monoaminergic/peptidergic modulation of simple behaviors using the well characterized and genetically-tractable Caenorhabditis elegans model system. Octopamine (OA), often considered the invertebrate equivalent to noradrenaline, inhibits key behaviors in C. elegans and often acts antagonistically to serotonin (5-HT). However, virtually nothing is known about the individual OA receptors or neuronal circuits involved in this modulation. In the present study, tyramine (TA) and OA each independently abolish 5-HT dependent increases in aversive responses mediated by a single pair of nociceptive ASH sensory neurons. Octopaminergic inhibition of ASH-mediated aversive responses involves three α -adrenergic-like OA receptors, OCTR-1, SER-6 and SER-3, depending on the intensity of the initiating stimulus. At low levels of stimulation, OCTR-1 inhibits signaling in the ASHs directly through a Gαo dependent pathway and at increasing ASH stimulation a second OA receptor, SER-6, signals the release of inhibitory peptides from the ADL, AWB and ASI sensory neurons through a Gαs/q -dependent pathway. In addition, SER-3 opposes the action of OCTR-1 in the ASHs at higher exogenous OA concentrations. Specifically, the OA and SER-6 -dependent release of peptides encoded by nlp-7 and 8 from the ADLs, nlp-9 from the AWBs and nlp-6, 7 and 9 from the ASIs is essential for maximal OA inhibition of aversive responses to 100% octanol. These studies highlight the complexity of octopaminergic/peptidergic interactions in the translation of nutritional state to the modulation of aversive behavior and suggest that the OA modulation of ASH-mediated aversive behavior may be an excellent model to examine the mechanism(s) that prevent the overstimulation of sensory mediated circuits. 2010-09-03 English text University of Toledo / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279208105 http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279208105 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
monoamines
neuropeptides
chemosensation
spellingShingle Biology
monoamines
neuropeptides
chemosensation
Wragg, Rachel T.
Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans
author Wragg, Rachel T.
author_facet Wragg, Rachel T.
author_sort Wragg, Rachel T.
title Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans
title_short Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans
title_full Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans
title_fullStr Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans
title_full_unstemmed Monoamines and Peptides Interact to Inhibit Glutamatergic Signaling in Caenorhabditis elegans
title_sort monoamines and peptides interact to inhibit glutamatergic signaling in caenorhabditis elegans
publisher University of Toledo / OhioLINK
publishDate 2010
url http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279208105
work_keys_str_mv AT wraggrachelt monoaminesandpeptidesinteracttoinhibitglutamatergicsignalingincaenorhabditiselegans
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