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ndltd-OhioLink-oai-etd.ohiolink.edu-toledo1271361311
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ndltd-OhioLink-oai-etd.ohiolink.edu-toledo12713613112021-08-03T06:07:33Z Development of Titania Nanofibers and Films for the Mitigation of Wound Infection Hershey, Ryan Anthony Disease-carrying pathogens in the body not only destroy healthy tissue but can eventually multiply and spread throughout the blood stream causing infection. Infections can be reduced and healing accelerated by using a nanotechnological approach with photoactive antimicrobial materials. In order to achieve this, two different approaches exploiting the known photoactive antimicrobial attributes of titanium dioxide (TiO2, also known as titania) were conceived. These are: (i) the development of non-woven nanofibers of titanium dioxide (TiO2), either in pristine or in doped form; this could be used as disinfectant gauze for wound healing upon activation by a pocket IR flashlight, and, (ii) the development of a simple and benign procedure for creating nanotubular or nanofibrillar structure of photoactive TiO2 on the surface of the implants (made from Ti or Ti6Al4V alloys).In the first case, the technique of electrospinning was used for fabricating non-woven TiO2 mesh, using titanyl nitrate as a benign and inexpensive precursor. In the second case, nanoscale TiO2 film formation on Ti-implants was achieved either by hydrothermal processing under very mild and benign experiment conditions or by anodization in the presence of dilute mineral acids and under mild voltages.Systematic and thorough structural and microstructural characterization was performed on the as-spun and the fired nanomats as well as on the films grown on the Ti coupons. Results pertaining to the biocidal activities of the self-standing nanofibers and the films on the Ti coupons showed significant decrease in the population of the E. coli cell colonies upon exposure of their aqueous broths to IR radiation for 3-12 seconds.Consequently, by interposing an effective procedure based on nanotechnology, the use of orthopedic and spinal implants can be made safer allowing bone healing to occur even faster, eliminating the probability of wound infection during and after surgical procedures. 2010-06-14 English text University of Toledo / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271361311 http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271361311 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
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NDLTD
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| language |
English
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NDLTD
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| author |
Hershey, Ryan Anthony
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Hershey, Ryan Anthony
Development of Titania Nanofibers and Films for the Mitigation of Wound Infection
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| author_facet |
Hershey, Ryan Anthony
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| author_sort |
Hershey, Ryan Anthony
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| title |
Development of Titania Nanofibers and Films for the Mitigation of Wound Infection
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| title_short |
Development of Titania Nanofibers and Films for the Mitigation of Wound Infection
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| title_full |
Development of Titania Nanofibers and Films for the Mitigation of Wound Infection
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| title_fullStr |
Development of Titania Nanofibers and Films for the Mitigation of Wound Infection
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| title_full_unstemmed |
Development of Titania Nanofibers and Films for the Mitigation of Wound Infection
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| title_sort |
development of titania nanofibers and films for the mitigation of wound infection
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| publisher |
University of Toledo / OhioLINK
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| publishDate |
2010
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| url |
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271361311
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AT hersheyryananthony developmentoftitaniananofibersandfilmsforthemitigationofwoundinfection
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1719431332707172352
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