The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors
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University of Toledo / OhioLINK
2009
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=toledo1250207420 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-toledo12502074202021-08-03T06:07:33Z The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors Ronquillo, Yasmyne Castillo Biology Malignant transformation salivary gland tumors Pleomorphic adenoma Gene Tumors of the salivary glands are some of the most complex tumors known. Although the progression from a benign salivary gland tumor to a malignancy has been documented in the literature, this process is not well understood. Pleomorphic adenoma (PA) is a type of benign tumor known clinically and histopathologically to transform into a malignant form in both the salivary glands and lacrimal glands. Pleomorphic Adenoma Gene 1 (PLAG1) overexpression is the initial abnormality found in PA. The molecular changes in the progression from PA to early stages of malignancy have not been fully elucidated. However, the inactivation of tumor suppressor genes and the activation of oncogenes and proto-oncogenes appear to be involved in the early transition phase to malignancy. The inactivation of p53, the loss of DCC, p16 and the activation of the oncogenes p21, c-myc and c-ras have been documented in cell culture, animal studies and human salivary gland tumors. In the intermediate and late stage of the transformation of PA to a malignant carcinoma ex pleomorphic adenoma (CXPA), the cell cycle genes CDC25A, erb-2, cdk-4, E2F-1, Bub-1, STAT3 are involved. The receptors PDGFR, Her-2/neu, androgen receptor and BRST-2 receptor are upregulated in some malignant tumors of the salivary gland. A model for the malignant transformation of pleomorphic adenoma to carcinoma is proposed. This model is analogous to the multi-stage tumorigenesis model of colon cancer. The studies of salivary gland tumors can serve as templates for the study of the malignant transformation in lacrimal gland tumors, the literature of which is sparse. 2009-09-23 English text University of Toledo / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=toledo1250207420 http://rave.ohiolink.edu/etdc/view?acc_num=toledo1250207420 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biology Malignant transformation salivary gland tumors Pleomorphic adenoma Gene |
| spellingShingle |
Biology Malignant transformation salivary gland tumors Pleomorphic adenoma Gene Ronquillo, Yasmyne Castillo The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors |
| author |
Ronquillo, Yasmyne Castillo |
| author_facet |
Ronquillo, Yasmyne Castillo |
| author_sort |
Ronquillo, Yasmyne Castillo |
| title |
The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors |
| title_short |
The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors |
| title_full |
The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors |
| title_fullStr |
The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors |
| title_full_unstemmed |
The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors |
| title_sort |
mechanisms of malignant transformation in benign salivary gland tumors |
| publisher |
University of Toledo / OhioLINK |
| publishDate |
2009 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1250207420 |
| work_keys_str_mv |
AT ronquilloyasmynecastillo themechanismsofmalignanttransformationinbenignsalivaryglandtumors AT ronquilloyasmynecastillo mechanismsofmalignanttransformationinbenignsalivaryglandtumors |
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