DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION

Bibliographic Details
Main Author:	Oliver, Andrea J.
Language:	English
Published:	Ohio University Honors Tutorial College / OhioLINK 2019
Subjects:	Chemistry
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors155628307940716

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-ouhonors1556283079407162021-08-03T07:10:49Z DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION Oliver, Andrea J. Chemistry Despite the constant development of new antibiotics, difficulties are encountered almost immediately through the development of antibiotic resistance. Researchers must constantly work to develop new antibiotics, while diversifying old antibiotic structures in order to avoid a global crisis caused by the generation of multidrug resistant organisms. This work described in this thesis attempts to diversify inexpensive, macrolide antibiotic scaffolds such as roxithromycin and spiramycin through the removal of sugar moieties, the functionalization of the existing ring and other structural changes. 2019 English text Ohio University Honors Tutorial College / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors155628307940716 http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors155628307940716 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Chemistry
spellingShingle	Chemistry Oliver, Andrea J. DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION
author	Oliver, Andrea J.
author_facet	Oliver, Andrea J.
author_sort	Oliver, Andrea J.
title	DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION
title_short	DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION
title_full	DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION
title_fullStr	DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION
title_full_unstemmed	DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION
title_sort	diversification of antibiotic scaffolds spiramycin and roxithromycin through carbenoid functionalization
publisher	Ohio University Honors Tutorial College / OhioLINK
publishDate	2019
url	http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors155628307940716
work_keys_str_mv	AT oliverandreaj diversificationofantibioticscaffoldsspiramycinandroxithromycinthroughcarbenoidfunctionalization
_version_	1719455894009282560

DIVERSIFICATION OF ANTIBIOTIC SCAFFOLDS SPIRAMYCIN AND ROXITHROMYCIN THROUGH CARBENOID FUNCTIONALIZATION

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