Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method

Bibliographic Details
Main Author:	Meng, Ziyuan
Language:	English
Published:	The Ohio State University / OhioLINK 2020
Subjects:	Chemistry polydopamine self assembly camptothecin rhodamine pH responsive
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=osu1607009248632196

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-osu16070092486321962021-10-15T05:10:51Z Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method Meng, Ziyuan Chemistry polydopamine self assembly camptothecin rhodamine pH responsive In the past decades, nanomedicines have attracted more and more attention due to its outstanding passive targeting property towards solid tumors by EPR (enhanced permeability and retention) effect which enables drugs accumulate more efficiently and prolongs the drug remaining time in cancer tissues. Among these nanomedicines, bio-inert materials were often used as excipients to achieve effective accumulation and passive targeting. These excipients are usually functionless except maintaining the nanostructures of drug delivery system. However, for self-assembled systems, the nanostructures are often maintained by drugs or functional molecules themselves without using excipients which will eliminate concerns of biocompatibility, toxicity and degradability of those carriers.In chapter one, the background of this research was introduced.In chapter two, polydopamine coating technique is discussed in great details. In the past, our group had some pioneer works on a self-assembled camptothecin lysine dipeptide conjugate (CPT-KK) which assembles into tubular form with diameters ranging from 80 nm to 120 nm with excellent anticancer activity. However, these CPT-KK tubes were not controllable in size, less stable in supramolecular structures and lack of active targetingability. To fix this, we have successfully coated CPT-KK tubes with polydopamine. With polydopamine coating, the length of these tubes was controlled by sonication, the supramolecular structures were stabilized and an interface for antibody binding were also provided which may potentially increase the active targeting ability of these tubes. This polydopamine coating method may also be applied to other self-assembled drug delivery systems for size control, supramolecular structure stabilization and antibody binding.In chapter three, novel self-assembled rhodamine-based pH responsive materials with excellent fluorescence properties is discussed. Typically, the extracellular pH is 7.3-7.4, the early endosome is ~6.3, the late endosome is ~5.5, and for pH in the lysosome is ~4.7. Materials responding to these exterior pH changes were often used for delivering drug into specific organelles in the cells. At the same time, pH in tumor microenvironments was reported to be more acidic than normal tissues. This encouraged more and more scientists to develop acid responsive materials for anti-cancer drug delivery. Here, two molecules RKK and RKE were designed. Both molecules adopt open-ring form which do not assemble into nanostructures in acidic condition and have a strong emission at 582 nm when excited at 550 nm. However, in basic conditions, both molecules have close-ring form which assembles into tubular form with assembly induced emission at 454 nm when excited at 330 nm. pH responsive assembly with different fluorescence mechanisms enables both molecules to be great drug delivery carrier with tracking ability and may potentially be used for delivering drug or genes into living cells. 2020 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1607009248632196 http://rave.ohiolink.edu/etdc/view?acc_num=osu1607009248632196 restricted--full text unavailable until 2026-01-08 This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Chemistry polydopamine self assembly camptothecin rhodamine pH responsive
spellingShingle	Chemistry polydopamine self assembly camptothecin rhodamine pH responsive Meng, Ziyuan Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method
author	Meng, Ziyuan
author_facet	Meng, Ziyuan
author_sort	Meng, Ziyuan
title	Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method
title_short	Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method
title_full	Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method
title_fullStr	Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method
title_full_unstemmed	Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method
title_sort	self-assembled nanostructures for drug delivery and its surface modification method
publisher	The Ohio State University / OhioLINK
publishDate	2020
url	http://rave.ohiolink.edu/etdc/view?acc_num=osu1607009248632196
work_keys_str_mv	AT mengziyuan selfassemblednanostructuresfordrugdeliveryanditssurfacemodificationmethod
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Self-assembled Nanostructures for Drug Delivery and its Surface Modification Method

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