Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers

Bibliographic Details
Main Author:	Rausch, Jamie Ann
Language:	English
Published:	The Ohio State University / OhioLINK 2020
Subjects:	Nursing Leptin Adiponectin EPA DHA Chronic Venous Leg Ulcers Leptin to adiponectin Ratio Wound Healing Inflammation
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=osu158652907707218

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-osu1586529077072182021-08-03T07:14:18Z Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers Rausch, Jamie Ann Nursing Leptin Adiponectin EPA DHA Chronic Venous Leg Ulcers Leptin to adiponectin Ratio Wound Healing Inflammation Background: Chronic venous leg ulcers (CVLUs) are debilitating wounds affecting nearly 9.7 million people worldwide, mainly older adults. Novel treatment approaches are needed because the incidence of CVLUs is rising and standard topical therapies are often ineffective. Chronic systemic and local inflammation are involved in the pathobiology of CVLUs. Potential targets for adjunct oral therapies include leptin and adiponectin, two hormones in systemic circulation involved in inflammation regulation. Higher leptin to adiponectin ratios (LARs) are associated with more inflammation. Some studies have shown that supplementing diets with marine omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has beneficial effects on LARs, however the collective findings are inconclusive. Thus, the primary purpose of this secondary analysis of data from a randomized clinical trial (RCT), was to determine effects of EPA+DHA supplementation on LARs in older adults with CVLUs.Methods: The parent study evaluated the effects of EPA+DHA (3.0 g/d) versus placebo on lipid mediators of inflammation and CVLU healing at 0, 4, and 8 weeks (n = 40). While leptin and adiponectin were not the primary outcomes variables in the parent study, plasma levels were quantified at the three study time points for 32 participants. Therefore, for this dissertation study, statistical methods were used to analyze the existing leptin and adiponectin data to determine effects of daily oral EPA+DHA supplementationiiiversus placebo on circulating levels of leptin, adiponectin, and LARs, and to evaluate associations between leptin, adiponectin, LARs, biomarkers of inflammation (proinflammatory cytokines), and percent of wound healing.Results: On average, participants (n = 32) were white (62.5%), obese (BMI: M = 41.5), older (age: M = 61.3), males (62.5%) with a history of cardiovascular disease. There were no differences in sociodemographic data between the two groups. As expected, plasma levels of EPA+DHA were significantly higher at week 4 (p < .001) and week 8 (p < .001) relative to week 0 in the EPA+DHA group. While there were no significant changes in individual levels of leptin or adiponectin in the EPA+DHA group across the study interval, the mean LAR was reduced by 23% at week 8 compared to week 4 (p = .06). Additionally, there was a significant negative correlation between adiponectin and IL-1β at week 4 (p = .02) and TNF-α at week 8 (p = .03) in the EPA+DHA group.Conclusion: Study findings suggest supplementing diets with EPA+DHA reduces LARs in older obese adults with CVLUs. The strong negative correlation noted between adiponectin and IL-1β and adiponectin and TNF-α suggests that adiponectin has anti-inflammatory actions, a finding aligned with some previous RCTs. Neither leptin nor adiponectin was associated with percent of wound healing in the current study. Future studies using larger samples, high versus low doses of EPA+DHA, for treatment periods longer than eight weeks, controlling for factors that may affect leptin and adiponectin, are needed to more clearly elucidate effects of EPA+DHA supplementation on leptin, adiponectin, and LAR in older and middle-aged adults with chronic inflammatory conditions. 2020-09-02 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu158652907707218 http://rave.ohiolink.edu/etdc/view?acc_num=osu158652907707218 restricted--full text unavailable until 2025-05-13 This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Nursing Leptin Adiponectin EPA DHA Chronic Venous Leg Ulcers Leptin to adiponectin Ratio Wound Healing Inflammation
spellingShingle	Nursing Leptin Adiponectin EPA DHA Chronic Venous Leg Ulcers Leptin to adiponectin Ratio Wound Healing Inflammation Rausch, Jamie Ann Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers
author	Rausch, Jamie Ann
author_facet	Rausch, Jamie Ann
author_sort	Rausch, Jamie Ann
title	Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers
title_short	Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers
title_full	Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers
title_fullStr	Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers
title_full_unstemmed	Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers
title_sort	secondary data analysis investigating effects of marine omega-3 fatty acidson circulating levels of leptin and adiponectin in older adultswith chronic venous leg ulcers
publisher	The Ohio State University / OhioLINK
publishDate	2020
url	http://rave.ohiolink.edu/etdc/view?acc_num=osu158652907707218
work_keys_str_mv	AT rauschjamieann secondarydataanalysisinvestigatingeffectsofmarineomega3fattyacidsoncirculatinglevelsofleptinandadiponectininolderadultswithchronicvenouslegulcers
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Secondary Data Analysis Investigating Effects of Marine Omega-3 Fatty Acidson Circulating Levels of Leptin and Adiponectin in Older Adultswith Chronic Venous Leg Ulcers

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