Development of New Novel Bacterial Topoisomerase Inhibitors as Promising Antibiotics with a 5-Amino-1,3-dioxane Linker Moiety

Development of New Novel Bacterial Topoisomerase Inhibitors as Promising Antibiotics with a 5-Amino-1,3-dioxane Linker Moiety

Bibliographic Details
Main Author:	Li, Linsen
Language:	English
Published:	The Ohio State University / OhioLINK 2019
Subjects:	Pharmacy Sciences
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=osu156336340053257

Similar Items

The molecular pharmacology of the topoisomerase II inhibitor etoposide in leukemia
by: Liu, Wai Man
Published: (2002)

Investigating the fluoroquinolone-topoisomerase interaction by use of novel fluoroquinolone and quinazoline analogs
by: Marks, Kevin Randall
Published: (2011)

2-Ethyl-5-triphenylmethyl-1,3-dioxane
by: Seik Weng Ng, et al.
Published: (2010-10-01)

Double Intramolecular Transacetalization of Polyhydroxy Acetals: Synthesis of Conformationally-Restricted 1,3-Dioxanes with Axially-Oriented Phenyl Moiety
by: Samuel Asare-Nkansah, et al.
Published: (2016-11-01)

2,2-Dimethyl-5-{[(4-nitrophenyl)amino]methylidene}-1,3-dioxane-4,6-dione
by: Ying-Hong Yang, et al.
Published: (2011-02-01)

5,5-Bis(hydroxymethyl)-2-phenyl-1,3-dioxane
by: Yi-Ming Luo, et al.
Published: (2008-08-01)

2,2-Dimethyl-5-triphenylmethyl-1,3-dioxane
by: Xing-Ming Liu, et al.
Published: (2009-02-01)

2-(2-Nitrophenyl)-1,3-dioxan-5-ol
by: Jin Chen, et al.
Published: (2009-11-01)

The activity of fluoroquinolones against Streptococcus pneumoniae and purified type II Topoisomerases
by: George, John Terry
Published: (1999)

Syntheses and crystal structures of 2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid and 2,2,5-trimethyl-1,3-dioxane-5-carboxylic anhydride
by: Joseph A. Giesen, et al.
Published: (2020-01-01)

Conformational equilibria involving 2-amino-1,3-dioxans: steric control of the anomeric effect
by: Anthony J. Kirby, et al.
Published: (2001-11-01)

Antibiotic Diversity and Bacterial Resistance
by: Powell, James Patrick
Published: (2007)

Synthesis and evaluation of antibacterial activity of the dual-action agents : beta-lactamase inhibitors with cytotoxic agents or beta-lactam antibiotics
by: Wang, Danni
Published: (2001)

Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors.
by: Noemi D'Atanasio, et al.
Published: (2020-01-01)

2-(2-Chlorophenyl)-5-methyl-1,3-dioxane-5-carboxylic acid
by: Guo-Kai Jia, et al.
Published: (2012-07-01)

(2-tert-Butyl-5-hydroxymethyl-1,3-dioxan-5-yl)methanol
by: Berenice Vargas, et al.
Published: (2012-07-01)

2-(2-Naphthyl)-1,3-dioxane
by: Damien Thevenet, et al.
Published: (2010-02-01)

Synthesis and molecular docking studies of some novel Schiff bases incorporating 6-butylquinolinedione moiety as potential topoisomerase IIβ inhibitors
by: Hany M. Hassanin, et al.
Published: (2018-01-01)

Studies of the metabolism, anti-tumor activity and toxicity of compounds containing N-methyl moieties
by: Gescher, A.
Published: (1986)

Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant.
by: Barbara Arnò, et al.
Published: (2013-01-01)

(5-n-Heptyl-2-hydroxymethyl-1,3-dioxan-2-yl)methanol
by: Xian-You Yuan, et al.
Published: (2010-11-01)

(5-n-Hexyl-2-hydroxymethyl-1,3-dioxan-2-yl)methanol
by: Min Zhang, et al.
Published: (2010-11-01)

Application of Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-induced Cachexia
by: Tseng, Yu-Chou
Published: (2017)

Bacterial type I topoisomerases – biological function and potential use as targets for antibiotic treatments
by: Marcin Szafran, et al.
Published: (2013-03-01)

Arylmethylene hydrazine derivatives containing 1,3-dimethylbarbituric moiety as novel urease inhibitors
by: Keyvan Pedrood, et al.
Published: (2021-05-01)

Studies of bacterial DNA topoisomerases
by: Lynch, Anthony Simon
Published: (1989)

Influence of iron on bacterial infections in leukaemia
by: Yates, Jacqueline M.
Published: (1992)

Role of the Klebsiella aerogenes envelope in resistance to antibiotics and host defences
by: Williams, Paul
Published: (1983)

Synthesis, Antimicrobial Activity and Molecular Docking of Novel Thiourea Derivatives Tagged with Thiadiazole, Imidazole and Triazine Moieties as Potential DNA Gyrase and Topoisomerase IV Inhibitors
by: Heba E. Hashem, et al.
Published: (2020-06-01)

Prospective inhibitors of serine hydroxymethyltransferase
by: Tendler, Saul J. B.
Published: (1986)

Studies on bacterial lung infections in cystic fibrosis
by: Breuleux, Claire Emilie
Published: (2000)

Compatibility and stability of 8% amino acids solution in combination with electrolytes, vitamins and antibiotics
by: Schuetz, David Harold
Published: (1973)

An investigation of possible mechanisms of toxicity of the aminoglycoside antibiotics
by: Chahwala, Suresh B.
Published: (1981)

2,2-Dimethyl-5-(2-nitrobenzylidene)-1,3-dioxane-4,6-dione
by: Angel Mendoza, et al.
Published: (2013-01-01)

5-(4-Bromoanilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
by: Jian-You Shi, et al.
Published: (2009-10-01)

5-(2-Fluorobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
by: Wu-Lan Zeng, et al.
Published: (2009-10-01)

5-(4-Hydroxybenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
by: Wu-Lan Zeng
Published: (2010-09-01)

5-(4-Chloroanilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
by: Jin-Cheng Yang, et al.
Published: (2009-07-01)

2,2-Dimethyl-5-(2-naphthylaminomethylene)-1,3-dioxane-4,6-dione
by: Rui Li, et al.
Published: (2009-10-01)

5-(4-Fluorobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
by: Wu-Lan Zeng
Published: (2010-09-01)