Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease
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The Ohio State University / OhioLINK
2018
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1523296832882977 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu15232968328829772021-08-03T07:05:53Z Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease Van Law, Heather Ophthalmology Proliferative Vitreoretinopathy (PVR) is an inflammatory, fibrotic condition that develops after 5-10% of rhegmatogenous retinal detachments and is the main cause of failure of retinal detachment repair.<sup>1-4</sup> Though there are several known risk factors for PVR, it is not known which patients will develop PVR following RD surgery. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is an important mediator of inflammation throughout the body.<sup>5-8</sup> MIF polymorphisms, specifically –794 CATT repeat (rs5844572) and –173 G/C promoter (rs755622), lead to an increased expression of MIF and have been linked with disease severity in a multitude of systemic diseases including systemic lupus erythematosus (SLE)<sup>9</sup>, rheumatoid arthritis (RA)<sup>10-12</sup>, juvenile idiopathic arthritis (JIA)<sup>13</sup>, sarcoidosis<sup>14</sup>, scleroderma<sup>15</sup>, and spinal cord injury, among others. MIF vitreous levels are shown to be elevated in the vitreous and subretinal fluid of patients with PVR.<sup>16,17</sup> Our research aims to determine if the presence of specific MIF promoter polymorphisms leads to an increased risk of PVR development or ERM formation. 2018-08-15 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1523296832882977 http://rave.ohiolink.edu/etdc/view?acc_num=osu1523296832882977 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Ophthalmology |
| spellingShingle |
Ophthalmology Van Law, Heather Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease |
| author |
Van Law, Heather |
| author_facet |
Van Law, Heather |
| author_sort |
Van Law, Heather |
| title |
Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease |
| title_short |
Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease |
| title_full |
Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease |
| title_fullStr |
Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease |
| title_full_unstemmed |
Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease |
| title_sort |
macrophage migration inhibitory factor (mif) promoter polymorphisms in vitreoretinal disease |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2018 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1523296832882977 |
| work_keys_str_mv |
AT vanlawheather macrophagemigrationinhibitoryfactormifpromoterpolymorphismsinvitreoretinaldisease |
| _version_ |
1719453629746774016 |