Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015

Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015

Bibliographic Details
Main Author: Szablewski, Christine Marie
Language:English
Published: The Ohio State University / OhioLINK 2018
Subjects:
Animal Diseases
Animals
Public Health
RNA viruses
United States
agricultural fair
animal population groups
animals
disease outbreaks
influenza A virus
livestock
public health
respiratory infections
swine
zoonoses
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu151388886442666
id ndltd-OhioLink-oai-etd.ohiolink.edu-osu151388886442666
record_format oai_dc
spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu1513888864426662021-08-03T07:05:08Z Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015 Szablewski, Christine Marie Animal Diseases Animals Public Health RNA viruses United States agricultural fair animal population groups animals disease outbreaks influenza A virus livestock public health respiratory infections swine zoonoses Influenza A virus is a zoonotic pathogen whose introduction to humans from animals could potentially cause a pandemic. Animal-linage influenza A viruses (IAVs) that infect humans are referred to as variant IAVs, which are designated with a `v’ after the subtype. To better understand the epidemiology of IAV in exhibition swine and resulting H3N2v in humans, we performed a phylogenetic analysis using full genome sequences from 279 IAV isolates collected from exhibition swine in 5 states from 2013-2015 and 23 of the 25 H3N2v cases reported during those same years. Sixty-six fairs (23.7%) had at least one sample that was positive for IAV and 20 of those fairs (30.3%) had more than one IAV genotype circulating in the pigs. An overall 3-year prevalence of 9.7% (95% CI: 9.1-10.3) was observed. However, the prevalence of IAV in swine significantly decreased from 2014 to 2015 when the proportion of fairs with IAV infected pigs decreased from 30.14% (95% CI: 19.6-40.1) in 2014 to 13.5% (95% CI: 6.9-20.1) in 2015. We found 19 IAV genotypes infecting swine and 6 IAV genotypes in humans, with 5 genotypes in both host species. There was a positive correlation between the number of fairs at which a genotype was present among the pigs and the number of human cases of that same genotype. Additionally, we showed that H3N2v isolates clustered tightly with exhibition swine isolates that were prevalent in the same year. Our data indicate that there are multiple genotypes of swine-lineage IAV that can infect humans, and highly prevalent IAV genotypes during a given year are the strains most likely to infect humans. 2018-06-14 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu151388886442666 http://rave.ohiolink.edu/etdc/view?acc_num=osu151388886442666 restricted--full text unavailable until 2023-05-18 This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Animal Diseases
Animals
Public Health
RNA viruses
United States
agricultural fair
animal population groups
animals
disease outbreaks
influenza A virus
livestock
public health
respiratory infections
swine
zoonoses
spellingShingle Animal Diseases
Animals
Public Health
RNA viruses
United States
agricultural fair
animal population groups
animals
disease outbreaks
influenza A virus
livestock
public health
respiratory infections
swine
zoonoses
Szablewski, Christine Marie
Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015
author Szablewski, Christine Marie
author_facet Szablewski, Christine Marie
author_sort Szablewski, Christine Marie
title Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015
title_short Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015
title_full Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015
title_fullStr Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015
title_full_unstemmed Evolution of Influenza A Viruses in Exhibition Swine and Transmission to Humans, 2013-2015
title_sort evolution of influenza a viruses in exhibition swine and transmission to humans, 2013-2015
publisher The Ohio State University / OhioLINK
publishDate 2018
url http://rave.ohiolink.edu/etdc/view?acc_num=osu151388886442666
work_keys_str_mv AT szablewskichristinemarie evolutionofinfluenzaavirusesinexhibitionswineandtransmissiontohumans20132015
_version_ 1719453311874105344

Similar Items