Measurement and Variation of the Mechanical Environment in Glioblastoma

Measurement and Variation of the Mechanical Environment in Glioblastoma

Bibliographic Details
Main Author: Calhoun, Mark A., II
Language:English
Published: The Ohio State University / OhioLINK 2017
Subjects:
Biomedical Engineering
Mechanobiology
Tumor Microenvironment
Glioblastoma
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu15032527351205062021-08-03T07:03:57Z Measurement and Variation of the Mechanical Environment in Glioblastoma Calhoun, Mark A., II Biomedical Engineering Biomedical Engineering Mechanobiology Tumor Microenvironment Glioblastoma Glioblastoma is a highly lethal brain tumor for which patient survival times have remained around 14 months for the past 40 years. The lethality of the disease is driven by the invasive nature of the tumor, which results in substantial infiltration throughout the brain parenchyma. These cells that are migrating further from the tumor are able to avoid surgical resection and radiotherapy. As a result, this places a greater burden on chemotherapy to eradicate the remaining tumor cells. Most often, temozolomide(TMZ), the gold standard chemotherapeutic, fails to meet this objective and a treatment-resistant tumor recurs, to which the vast majority of patients will succumb. The problem with chemotherapy is two-fold. First, TMZ is a genotoxic drug, so tumor cells that are resistant to DNA damage-induced apoptosis are able to survive and serve as the genetic basis of the recurrent tumor. In order to eliminate enough tumor cells to prevent a recurrent tumor, new drug targets are needed. Combination therapy has been the most effective approach to cancer treatment (i.e. surgery, radiation, and chemotherapy) and it is likely that the future of glioblastoma research will involve additional chemotherapies. Second, drug delivery to the brain is poor because of the blood-brain barrier (BBB). Therefore, this dissertation has characterized and probed the mechanical microenvironment to build towards new drug targets for patient treatment. Additionally, a drug carrier is characterized for its ability to cross the BBB, to improve drug delivery to the brain. 2017 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506 http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection NDLTD
language English
sources NDLTD
topic Biomedical Engineering
Biomedical Engineering
Mechanobiology
Tumor Microenvironment
Glioblastoma
spellingShingle Biomedical Engineering
Biomedical Engineering
Mechanobiology
Tumor Microenvironment
Glioblastoma
Calhoun, Mark A., II
Measurement and Variation of the Mechanical Environment in Glioblastoma
author Calhoun, Mark A., II
author_facet Calhoun, Mark A., II
author_sort Calhoun, Mark A., II
title Measurement and Variation of the Mechanical Environment in Glioblastoma
title_short Measurement and Variation of the Mechanical Environment in Glioblastoma
title_full Measurement and Variation of the Mechanical Environment in Glioblastoma
title_fullStr Measurement and Variation of the Mechanical Environment in Glioblastoma
title_full_unstemmed Measurement and Variation of the Mechanical Environment in Glioblastoma
title_sort measurement and variation of the mechanical environment in glioblastoma
publisher The Ohio State University / OhioLINK
publishDate 2017
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506
work_keys_str_mv AT calhounmarkaii measurementandvariationofthemechanicalenvironmentinglioblastoma
_version_ 1719452865260421120

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