HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly

HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly

Bibliographic Details
Main Author: Liu, Shuohui
Language:English
Published: The Ohio State University / OhioLINK 2017
Subjects:
Chemistry
HIV 1 Gag Binding Specificity
Salt-titration binding assays
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1492171451527208
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu14921714515272082021-08-03T07:01:44Z HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly Liu, Shuohui Chemistry HIV 1 Gag Binding Specificity Salt-titration binding assays Human immunodeficiency virus type 1 (HIV-1) Gag is a polyprotein consisting of matrix (MA), capsid (CA), nucleocapsid (NC) and p6 domains, as well as two short spacer peptides, SP1 and SP2. During virus assembly, two copies of viral genomic RNA (gRNA) are selectively packaged into viral particles via specific interactions between Gag and gRNA packaging signal, despite the vast abundance of cellular RNAs and spliced viral RNAs. However, the mechanism by which Gag specifically recognizes gRNA is not completely understood. In this study, several elements that are important for Gag’s binding specificity for gRNA packaging signal were investigated using salt-titration binding assays. 2017-10-31 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1492171451527208 http://rave.ohiolink.edu/etdc/view?acc_num=osu1492171451527208 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Chemistry
HIV 1 Gag Binding Specificity
Salt-titration binding assays
spellingShingle Chemistry
HIV 1 Gag Binding Specificity
Salt-titration binding assays
Liu, Shuohui
HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly
author Liu, Shuohui
author_facet Liu, Shuohui
author_sort Liu, Shuohui
title HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly
title_short HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly
title_full HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly
title_fullStr HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly
title_full_unstemmed HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly
title_sort hiv-1 gag binding specificity for psi: implications for virus assembly
publisher The Ohio State University / OhioLINK
publishDate 2017
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1492171451527208
work_keys_str_mv AT liushuohui hiv1gagbindingspecificityforpsiimplicationsforvirusassembly
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