Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides

Bibliographic Details
Main Author:	Nappi, Mary
Language:	English
Published:	The Ohio State University / OhioLINK 2016
Subjects:	Chemistry
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=osu1451497452

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-osu14514974522021-08-03T06:34:36Z Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides Nappi, Mary Chemistry Self-assembly is crucial to numerous systems that occur in nature; researchers have often attempted to mimic these natural systems by utilizing non-covalent interactions of amphiphilic systems to form self-assembled structures in solution for useful applications. The Parquette group has discovered a self assembling 1,4,5,8-naphthalenediimide (NDI) diacetylene system with a lysine unit that assembles into a robust one-dimensional nanotube, capable of acting as a surfactant for gold nanoparticle growth. The diacetylene unit is capable of polymerization, as well as changing its conformation to sheets after heating; regardless of the shape or polymerization status of the nanostructures, they were able to act as a stabilized surface for gold nanoparticle growth. Other groups have discovered that gold nanoparticles are attracted to amine functionality electrostatically, decorating the surface of a surfactant. However, there are few examples of self-assembled systems forming nanostructures that can withstand the slightly acidic Turkevich method of reducing gold (III) into gold (0) using citric acid or citrate.Stimuli-responsive materials have been of interest in recent years, due to the interest in mimicking various types of biological systems for different applications. Self-assembling systems are an interesting approach to this research due to its ability to create highly ordered systems quickly. Stimuli-responsive materials react to their chemical and physical environments; therefore, by manipulation of a molecular structure, it is possible to develop a unique set of compounds that react to their environments for applications in optoelectronics, drug delivery, or bio-mimics. In this work, two tetrapeptides with the sequence Phe-Lys-Lys(TPP-Zn)-Lys were developed using a tetraphenylporphyrin ring on the third lysine tail. The difference in the peptides was that one had a free amine on the lysine adjacent to the phenylalanine amino acid, while the other peptide had an acyl-protecting group on the lysine adjacent to the phenylalanine. Due to the Zn-TPP chromophore on the assembly, nitrogen-containing ligands were used to make the structure more defined. With the addition of DABCO or pyridine, the observed structures based on microscopy methods changed depending on the conditions. The tetrapeptides formed ß-sheet structures based on IR data; since anti-parallel and parallel ß-sheets are possible, an isotopic equivalent of each tetrapeptide was synthesized and analyzed by IR. A splitting of the amide I band demonstrates the formation of anti-parallel ß-sheets when the isotope is used; in this case, the amide I band split for both isotopic equivalents indicating anti-parallel ß-sheet formation. 2016-06-08 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1451497452 http://rave.ohiolink.edu/etdc/view?acc_num=osu1451497452 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Chemistry
spellingShingle	Chemistry Nappi, Mary Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides
author	Nappi, Mary
author_facet	Nappi, Mary
author_sort	Nappi, Mary
title	Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides
title_short	Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides
title_full	Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides
title_fullStr	Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides
title_full_unstemmed	Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides
title_sort	decoration of amphiphilic ndi-diacetylene nanotubes with gold nanoparticles and the anti-parallel ß-sheet assembly of porphyrin modified tetrapeptides
publisher	The Ohio State University / OhioLINK
publishDate	2016
url	http://rave.ohiolink.edu/etdc/view?acc_num=osu1451497452
work_keys_str_mv	AT nappimary decorationofamphiphilicndidiacetylenenanotubeswithgoldnanoparticlesandtheantiparallelßsheetassemblyofporphyrinmodifiedtetrapeptides
_version_	1719439624704622592

Decoration of Amphiphilic NDI-diacetylene Nanotubes with Gold Nanoparticles and the Anti-parallel ß-Sheet Assembly of Porphyrin Modified Tetrapeptides

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