Innovations en Route to Muironolide A

Bibliographic Details
Main Author:	Cunningham, Krista L.
Language:	English
Published:	The Ohio State University / OhioLINK 2015
Subjects:	Organic Chemistry Chemistry chemistry organic synthesis muironolide A
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=osu1437681625

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-osu14376816252021-08-03T06:32:20Z Innovations en Route to Muironolide A Cunningham, Krista L. Organic Chemistry Chemistry chemistry organic synthesis muironolide A Muironolide A is a complex natural product that was isolated from a marine sponge Phorbas sp. This sponge has yielded several potent anticancer drug leads, including the phorboxazoles. However, a very minute quantity of muironolide A was isolated – only 90 micrograms of purified material. Remarkably, this was sufficient for Professor T. Molinski to propose the complete structure, which includes an unprecedented hexahydro-1H-isoindolone skeleton, a chlorocyclopropane, and a trichlorocarbinol ester. However, the limited amount of material available has prevented evaluation of the biological activities of muironolide A. It is anticipated that the novel chemotype may have associated useful activities, given those of its natural product congeners. We are developing a convergent, biomimetic total synthesis of muironolide A and its close structural analogs to allow full evaluation of their biomedical potential. This involves the preparation of several component fragments and their successive couplings. 2015-10-01 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1437681625 http://rave.ohiolink.edu/etdc/view?acc_num=osu1437681625 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Organic Chemistry Chemistry chemistry organic synthesis muironolide A
spellingShingle	Organic Chemistry Chemistry chemistry organic synthesis muironolide A Cunningham, Krista L. Innovations en Route to Muironolide A
author	Cunningham, Krista L.
author_facet	Cunningham, Krista L.
author_sort	Cunningham, Krista L.
title	Innovations en Route to Muironolide A
title_short	Innovations en Route to Muironolide A
title_full	Innovations en Route to Muironolide A
title_fullStr	Innovations en Route to Muironolide A
title_full_unstemmed	Innovations en Route to Muironolide A
title_sort	innovations en route to muironolide a
publisher	The Ohio State University / OhioLINK
publishDate	2015
url	http://rave.ohiolink.edu/etdc/view?acc_num=osu1437681625
work_keys_str_mv	AT cunninghamkristal innovationsenroutetomuironolidea
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Innovations en Route to Muironolide A

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