A Retrospective Study of MDCT Chest Examinations with Two Different Doses of IV Contrast Media
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The Ohio State University / OhioLINK
2015
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu14277660622021-08-03T06:29:33Z A Retrospective Study of MDCT Chest Examinations with Two Different Doses of IV Contrast Media Thomas, Elinor Lynn Medical Imaging Medicine CT Chest MDCT Chest Enhanced CT Chest Iodine Contrast Media CIN Contrast Induced Nephropathy CIAKI Purpose: Chronic kidney disease (CKD), has been recognized as a global public health problem, and may affect up to 35% of the adult population worldwide. One method of lessening the occurrence of CKD is to decrease the incidence of Contrast Induced Acute Kidney Injury (CIAKI) which occurs when acute renal dysfunction is diagnosed after the intravascular injection of water soluble iodinated contrast media during radiologic examinations. Since CIAKI occurs in up to 15 percent of the general population receiving intravascular iodine-based contrast agents, recommendations include the use of the lowest possible dose of iso-osmolal or selected low-osmolal contrast. Based on these recommendations and guidelines, it is important to identify methods to decrease the dose of intravascular contrast for radiologic exams in order to lessen the possibility of adverse kidney events. The purpose of this study is to compare the quality and diagnostic capabilities for which two contrast-enhanced routine MDCT chest scans were performed, using two different doses of iodinated water soluble IV contrast media.Methods: This was a retrospective study of an existing image database to compare image quality of two routine contrast-enhanced MDCT chest scans, each performed on the same patient using two different doses of water soluble IV contrast media, one with 100mL of high concentration iodinated IV contrast media, and one with 75mL of high concentration iodinated IV contrast media. The diagnostic image quality was evaluated based upon image contrast resolution as measured by regions of interest (ROI’s) in Hounsfield Units (HU’s) of the ascending aorta, the pulmonary root and the descending aorta; and an acceptable diagnostic image quality as subjectively interpreted by two radiologists, using a standardized 3-point image quality scaleResults: When calculating for a statistical difference in contrast between the 75mL and 100mL contrast exams, the independent samples t-test results demonstrated that there is a statistically significant difference in the HU’s between the 100mL contrast dose and the 75mL contrast dose (p < .05). However, the results also demonstrated that the subjective radiologist readings of the CT chest scans utilizing 75mL doses, answered the clinical questions and were diagnostically satisfactory. Conclusions: Therefore, this study suggests that CT chest protocols may be adjusted from 100mL to 75mL, by lowering the overall amount of high concentration iodinated contrast media by 25mL, utilizing similar updated CT scanners and patient weights of 210 kilograms or less without degrading the image quality or the ability of the radiologist to make a diagnostic interpretation. Future prospective studies should include iodinated IV contrast dosing based on individual patient needs and characteristics. 2015-05-21 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1427766062 http://rave.ohiolink.edu/etdc/view?acc_num=osu1427766062 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Medical Imaging Medicine CT Chest MDCT Chest Enhanced CT Chest Iodine Contrast Media CIN Contrast Induced Nephropathy CIAKI |
| spellingShingle |
Medical Imaging Medicine CT Chest MDCT Chest Enhanced CT Chest Iodine Contrast Media CIN Contrast Induced Nephropathy CIAKI Thomas, Elinor Lynn A Retrospective Study of MDCT Chest Examinations with Two Different Doses of IV Contrast Media |
| author |
Thomas, Elinor Lynn |
| author_facet |
Thomas, Elinor Lynn |
| author_sort |
Thomas, Elinor Lynn |
| title |
A Retrospective Study of MDCT Chest Examinations with Two Different Doses of IV Contrast Media |
| title_short |
A Retrospective Study of MDCT Chest Examinations with Two Different Doses of IV Contrast Media |
| title_full |
A Retrospective Study of MDCT Chest Examinations with Two Different Doses of IV Contrast Media |
| title_fullStr |
A Retrospective Study of MDCT Chest Examinations with Two Different Doses of IV Contrast Media |
| title_full_unstemmed |
A Retrospective Study of MDCT Chest Examinations with Two Different Doses of IV Contrast Media |
| title_sort |
retrospective study of mdct chest examinations with two different doses of iv contrast media |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2015 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1427766062 |
| work_keys_str_mv |
AT thomaselinorlynn aretrospectivestudyofmdctchestexaminationswithtwodifferentdosesofivcontrastmedia AT thomaselinorlynn retrospectivestudyofmdctchestexaminationswithtwodifferentdosesofivcontrastmedia |
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