Surface Tension Measurements of Various Surfactants Using the Constrained Sessile Drop Method
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
The Ohio State University / OhioLINK
2014
|
| Subjects: | |
| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=osu1398819754 |
| id |
ndltd-OhioLink-oai-etd.ohiolink.edu-osu1398819754 |
|---|---|
| record_format |
oai_dc |
| spelling |
ndltd-OhioLink-oai-etd.ohiolink.edu-osu13988197542021-08-03T06:24:19Z Surface Tension Measurements of Various Surfactants Using the Constrained Sessile Drop Method Robson, Alyssa A. Chemistry Respiratory distress syndromes affects over 150, 000 patients a year, and is the result of lung injury which typically results in inhibition or inactivation of pulmonary surfactant (PS). PS is composed of lipids and proteins, and is located near the liquid lining in the lungs. When the PS becomes inhibited or inactivated breathing becomes difficult. PS lowers the surface tension in the lungs during breathing, and low surface tension is central to any surfactant replacement therapy (SRT) for respiratory distress syndrome. Current SRTs, which vary in source and composition, do not greatly improve the recovery or mortality of adolescent and adult patients. This is due in part to the lack of knowledge of how PS, and the individual components, perform in the lungs to lower the surface tension. Additionally, SRT is placed in lungs which have inhibited or inactivated PS. For example, if the endogenous PS is inhibited and synthetic surfactant is administered to the lungs, inhibition could happen to the SRT, which does not improve the recovery of the patient, therefore, a superior treatment is needed. Constrained sessile drop (CSD) is a unique way to study PS components and analogs since the surface tension of a spherical drop is measured. The alveoli in the lungs closely resemble a cluster of bulbous grapes, and the alveoli expand and contract during breathing. A constrained sessile drop is able to mimic an alveolus during respiration by changing the volume of a drop, called cycling, at rates comparable to that of breathing. In this thesis, water was the first liquid that was studied using CSD since the surface tension of water is well documented. Once constant and reliable surface tension values were measured for both static and dynamic water drops, surfactant thin films were studied. Two PS components, dipalmitoylphosphatidylcholine (DPPC) and cholesterol, were studied by way of water drops with different concentrations of a thin coating of surfactant. Static measurements were studied with higher concentrations to ensure proper drop deformation and to verify that obtaining surface tension values lower than that of water were possible. Preliminary compression isotherms were also conducted for DPPC and cholesterol. Lipopolysaccharide was a third surfactant studied using CSD; static and dynamic drops were studied. Overall, the CSD setup functions well and is capable of forming pure water drops as well as those with surfactant thin films. Surface tension measurements obtained for water are consistent with those published. The surface tension values for surfactant thin films can be measured and compression isotherms similar to those measured using a Langmuir trough are possible. 2014 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1398819754 http://rave.ohiolink.edu/etdc/view?acc_num=osu1398819754 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Chemistry |
| spellingShingle |
Chemistry Robson, Alyssa A. Surface Tension Measurements of Various Surfactants Using the Constrained Sessile Drop Method |
| author |
Robson, Alyssa A. |
| author_facet |
Robson, Alyssa A. |
| author_sort |
Robson, Alyssa A. |
| title |
Surface Tension Measurements of Various Surfactants Using the Constrained Sessile Drop Method |
| title_short |
Surface Tension Measurements of Various Surfactants Using the Constrained Sessile Drop Method |
| title_full |
Surface Tension Measurements of Various Surfactants Using the Constrained Sessile Drop Method |
| title_fullStr |
Surface Tension Measurements of Various Surfactants Using the Constrained Sessile Drop Method |
| title_full_unstemmed |
Surface Tension Measurements of Various Surfactants Using the Constrained Sessile Drop Method |
| title_sort |
surface tension measurements of various surfactants using the constrained sessile drop method |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2014 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1398819754 |
| work_keys_str_mv |
AT robsonalyssaa surfacetensionmeasurementsofvarioussurfactantsusingtheconstrainedsessiledropmethod |
| _version_ |
1719436418922577920 |